High retinoic acid receptor-related orphan receptor A gene expression in peripheral blood leukocytes may be related to acute myocardial infarction.

The Journal of International Medical Research
Heyu MengFanbo Meng

Abstract

This study aimed to investigate whether differential expression of the retinoic acid receptor-related orphan receptor A (RORA) gene is related to occurrence of acute myocardial infarction (AMI). This was a retrospective study. White blood cells of 93 patients with acute myocardial infarction and 74 patients with stable coronary artery disease were collected. Reverse transcription quantitative polymerase chain reaction and western blotting were used to measure RORA mRNA and protein expression, respectively. RORA mRNA expression levels in peripheral blood leukocytes in patients with AMI were 1.57 times higher than those in patients with stable coronary artery disease. Protein RORA levels in peripheral blood of patients with AMI were increased. Binary logistic regression analysis showed that high expression of RORA was an independent risk factor for AMI, and it increased the risk of AMI by 2.990 times. RORA expression levels in patients with AMI is significantly higher than that in patients with stable coronary artery disease. High expression of RORA is related to AMI and it may be an independent risk factor for AMI.

References

May 30, 2002·Thyroid : Official Journal of the American Thyroid Association·Leonidas H Duntas
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Anne R Cappola, Paul W Ladenson
Aug 11, 2004·Archives of Internal Medicine·Lars FrostLeif Mosekilde
Aug 10, 2006·The Journal of Clinical Hypertension·L Michael PrisantAnthony L Mulloy
Apr 18, 2008·Advances in Developmental Biology·Anton M Jetten, Joung Hyuck Joo
Oct 17, 2008·Genomic Medicine·Hamza AzizGeoffrey S Ginsburg
Jan 24, 2009·The Journal of Pharmacology and Experimental Therapeutics·Yuping ChenJoyce A Goldstein
Oct 1, 2008·Circulation. Cardiovascular Genetics·James A WingroveWilliam E Kraus
Jul 28, 2010·Circulation·Ezra A AmsterdamUNKNOWN American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology,
Jan 24, 2013·Thyroid : Official Journal of the American Thyroid Association·Greet L RoefErnst R Rietzschel
May 8, 2013·Current Topics in Medicinal Chemistry·Xuan XiaoKuo-Chen Chou
Sep 28, 2014·The American Journal of Medicine·Yariv GerberVéronique L Roger
Nov 21, 2014·Journal of Biological Rhythms·Jacques Philippe, Charna Dibner
Apr 20, 2016·Progress in Cardiovascular Diseases·Konstantinos Dean BoudoulasHarisios Boudoulas
Dec 21, 2016·Cardiovascular & Hematological Agents in Medicinal Chemistry·Miha TibautDaniel Petrovic
Nov 8, 2017·Chronobiology International·Rodrigo A Peliciari-GarciaMaria Tereza Nunes
Dec 13, 2018·Cytokine·Louise Correia LimaValdirene Leão Carneiro
Apr 17, 2019·The American Journal of Emergency Medicine·Tim MontriefBrit Long

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