High-risk cutaneous squamous cell carcinoma of the head and neck: results from 266 treated patients with metastatic lymph node disease

Cancer
Michael J VenessGary J Morgan

Abstract

Most patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck (HN) are at low-risk (<5%) of developing metastatic SCC to regional lymph nodes. However, patients with unfavorable clinicopathologic factors often are under appreciated by clinicians but remain at higher risk for developing metastatic lymph node disease and dying. Patients were identified who had metastatic cSCC to lymph nodes (parotid and cervical) of the HN and who were treated within the context of a multidisciplinary HN cancer service between 1980 and 2005 at Westmead Hospital (Sydney, Australia). Relevant patient details and data from primary lesions were analyzed and reported. In total, 266 patients were treated with curative intent. The median patient age was 69 years among 219 males and 47 females. The majority of metastatic lymph nodes (162 of 266 lymph nodes; 61%) were located in the parotid with or without cervical lymph node involvement. The median tumor thickness was 6 mm (range, 0.5-28 mm), and the median tumor size was 15 mm (range, 3-70 mm). Most tumors (65%) that measured >or=5 mm in thickness, and 30% of patients had lesions that measured >or=2 cm in greatest dimension. Recurrent cSCC was present in 15% of patients, and most lesi...Continue Reading

References

Nov 1, 1990·American Journal of Clinical Pathology·H BreuningerG Rassner
May 1, 1989·Head & Neck·R GroverJ H Shaw
Aug 1, 1989·Journal of the American Academy of Dermatology·S M Dinehart, S V Pollack
Apr 1, 1986·Human Pathology·H F Frierson, P H Cooper
Oct 1, 1984·American Journal of Surgery·H GoepfertM D Luna
Jan 1, 1994·Dermatology : International Journal for Clinical and Investigative Dermatology·D CzarneckiC Meehan
Feb 1, 1994·Journal of Cutaneous Pathology·A L Stein, S R Tahan
Feb 1, 1996·The Laryngoscope·E Tavin, M Persky
May 30, 1998·Archives of Otolaryngology--head & Neck Surgery·D H KrausL B Harrison
Nov 10, 1998·International Journal of Cancer. Journal International Du Cancer·P G Buettner, B A Raasch
Jan 12, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M OnerclG Gedikoğlu
Jun 10, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G Petter, U F Haustein
Jan 12, 2002·Archives of Otolaryngology--head & Neck Surgery·Luiz P Kowalski
Mar 19, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Basil S CherpelisPearon G Lang
May 11, 2002·Archives of Otolaryngology--head & Neck Surgery·Stephen Y LaiRandal S Weber
Feb 4, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Matthew J ReschlyNeil A Fenske
Mar 8, 2003·Archives of Dermatology·Juan-Carlos MartinezUNKNOWN Transplant-Skin Cancer Collaborative
Dec 4, 2003·Head & Neck·Allie Garcia-SerraAnthony A Mancuso
Jan 21, 2004·Archives of Dermatology·Jeffrey D WagnerJohn J Coleman
Sep 24, 2004·International Journal of Radiation Oncology, Biology, Physics·Winkle KwanVeronika Moravan
Jan 1, 2005·Journal of the American Academy of Dermatology·Richard C NolanPeter J Heenan
Feb 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary L ClaymanScott M Lippman
Mar 25, 2005·The British Journal of Dermatology·E de VriesJ W W Coebergh
Jul 20, 2005·Archives of Otolaryngology--head & Neck Surgery·Christopher J O'Brien
Sep 9, 2005·The Laryngoscope·Brian A MooreGary L Clayman

❮ Previous
Next ❯

Citations

Sep 25, 2009·The Journal of Laryngology and Otology·S J TurnerM J Veness
Jul 20, 2012·Nature Reviews. Cancer·Michael B Sporn, Karen T Liby
Aug 2, 2007·The American Journal of Dermatopathology·Ki-Young SuhPedram Gerami
Mar 25, 2011·The American Journal of Dermatopathology·Efthimios SivridisMichael I Koukourakis
Apr 7, 2007·Current Opinion in Otolaryngology & Head and Neck Surgery·Carsten E PalmeMichael J Veness
Apr 7, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Jeffrey Bumpous
May 14, 2008·Southern Medical Journal·Michel C TchanMahiban Thomas
May 15, 2008·Journal of Medical Imaging and Radiation Oncology·M J Veness
Feb 9, 2012·International Journal of Surgical Oncology·Smith ApisarnthanaraxD Neil Hayes
Dec 14, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Luigi Antonio ValdattaCarlo Fidanza
Nov 6, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Melissa Pugliano-Mauro, Glenn Goldman
Mar 18, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Carlos Garcia, A Neil Crowson
Jun 2, 2007·Journal of Biomedicine & Biotechnology·Michael J Veness
Dec 18, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Wai Keat Wong, Randall P Morton
May 15, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Aviram MizrachiGideon Bachar
May 11, 2011·Expert Review of Anticancer Therapy·Venura SamarasingheJohn T Lear
Oct 22, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Nigel Gordon Maher, Gary Russell Hoffman
May 21, 2013·Actas dermo-sifiliográficas·A Martorell-CalatayudC Guillén Barona
Nov 10, 2012·International Journal of Oral and Maxillofacial Surgery·A KošecI Lukšić
Jan 21, 2012·Actas dermo-sifiliográficas·A Nuño-GonzálezJ L López-Estebaranz
May 5, 2011·Seminars in Cutaneous Medicine and Surgery·Meena K Singh, Jerry D Brewer
Jul 6, 2010·Journal of the American Academy of Dermatology·Cristina RenziPaolo Pasquini
Mar 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Athanassios KyrgidisKonstantinos Antoniades
Aug 29, 2009·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Constantinos MourouzisClive Pratt
Aug 2, 2008·The Lancet Oncology·Michael J Veness
Nov 30, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C RenziP Pasquini
Jun 5, 2008·ANZ Journal of Surgery·Julie R HowleMichael J Veness
May 22, 2008·Journal of Surgical Oncology·Francisco CivantosAyman Amin
Dec 17, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·J J BonerandiUNKNOWN French Dermatology Recommendations Association (aRED)
May 18, 2012·Journal of Surgical Oncology·Nicholas D L S BroughamSwee T Tan
Mar 13, 2012·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Helmut BreuningerHans-Martin Häfner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.