High-Risk HPV Oncoproteins and PD-1/PD-L1 Interplay in Human Cervical Cancer: Recent Evidence and Future Directions

Frontiers in Oncology
Soumaya AllouchAla-Eddin Al Moustafa

Abstract

Cervical cancer is the fourth most common malignancy in women worldwide and a leading cause of cancer-related mortality in developing countries. Important etiological factors in this cancer are high-risk human papillomaviruses (HPV), as roughly 96% of cervical cancer cases are positive for these oncoviruses. On the other hand, it has been recently pointed out that E6/E7 oncoproteins of high-risk HPV can upregulate the programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) axis. Likewise, several recent reports showed that checkpoint blockades targeting PD-1/PD-L1 pathways have achieved efficient clinical responses via suppressing cancer progression and improving survival in several types of human cancers including metastatic cervical cancer. In this review, we summarize recent advances in our understanding of the PD-1/PD-L1 signaling pathway and its interaction with high-risk HPV and their oncoproteins, which could have an important impact on the management of HPV-associated cancers including cervical.

References

Apr 22, 2003·Nature Medicine·Tyler J CurielWeiping Zou
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yaguang XiJingfang Ju
Sep 5, 2006·Vaccine·D Maxwell Parkin, Freddie Bray
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi TazawaHitoshi Nakagama
Apr 15, 2008·FEBS Letters·Fang SunXiaofei Zheng
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Munekazu YamakuchiCharles J Lowenstein
Nov 15, 2008·Virology·Margaret E McLaughlin-Drubin, Karl Münger
May 12, 2009·Immunological Reviews·James L Riley
Sep 29, 2009·Nature Immunology·Brian T FifeJeffrey A Bluestone
May 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Baohua LiXing Xie
Jul 20, 2010·Immunological Reviews·Loise M FranciscoArlene H Sharpe
Jun 1, 2011·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Sytse J Piersma
Jun 5, 2012·The New England Journal of Medicine·Julie R BrahmerJon M Wigginton
Jul 19, 2012·The FEBS Journal·David PimLawrence Banks
Aug 18, 2012·Nature Reviews. Cancer·Heiko Hermeking
Feb 5, 2013·Advances in Experimental Medicine and Biology·Sabine HüntenHeiko Hermeking
Feb 21, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinchuan FangSufang Jin
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Ala-Eddin Al MoustafaGhazi Alsbeih
Jan 8, 2015·Scientific Reports·Chanzhen LiuKehkooi Kee
Feb 7, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nan ChenLi Zhang
Jun 7, 2015·Current Opinion in Pharmacology·Joel Sunshine, Janis M Taube
Jul 17, 2015·BioMed Research International·Joana RibeiroHugo Sousa
Aug 1, 2015·Nature Reviews. Drug Discovery·Kathleen M MahoneyGordon J Freeman
Sep 26, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Louisa MezacheGerard J Nuovo
Nov 19, 2015·Journal of the National Cancer Institute·Maria Angelica CortezJames W Welsh
Apr 9, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·A Marijne HeerenEkaterina S Jordanova
Aug 12, 2016·International Journal of Oncology·Zhiqiang PengJunfang Zheng
Aug 31, 2016·OncoTargets and Therapy·Xin WangJinming Yu

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Citations

Apr 24, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Louise FerrallT-C Wu

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Methods Mentioned

BETA
ELISA

Clinical Trials Mentioned

NCT02488759
NCT02628067
NCT03635567

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