High-Risk human papillomavirus genotype distribution in the Northern region of Portugal: Data from regional cervical cancer screening program

Papillomavirus Research
Hugo SousaRui Henrique

Abstract

High-Risk Human papillomavirus (HR-HPV) full genotyping methods have been described as of great potential use in epidemiology and preventive strategies, including cervical cancer screening and HPV vaccination. We characterized the prevalence and distribution of HR-HPV genotypes in cervico-vaginal samples obtained from the Regional Cervical Cancer Screening Program from the Northern Region of Portugal. HR-HPV genotyping was performed using Anyplex™ II HPV-HR Detection kit in 105,458 women enrolled between August 2016 and December 2017. HR-HPVs were detected in 10,665 women (10.2%) with a prevalence ranging from 6.2 to 17.1% depending on age, and from 8.7 to 10.7% depending on geographical location. Multiple infections with two or more HR-HPVs were detected in 2736 (25.7%) of HR-HPV women ranging from 16.5 to 31.0% depending on age. Amongst HR-HPV positive women, HPV-16 (17.5%), HPV-39 (16.7%), HPV-31 (15.0%), HPV-68 (13.2%), HPV-52 (10.7%) and HPV-51 (10.6%) were the most common genotypes in our population, being HPV-16 more frequent in women aged from 30 to 45 years and HPV-39 in 50-65 years. Results also show that HPV16/18 are present in 22.1% and HPV16/18/31/33/45/52/58 in 47.6% of HR-HPV positive women. This is the largest s...Continue Reading

Citations

Aug 17, 2020·Journal of Lower Genital Tract Disease·Conceição SaldanhaCarlos Sousa
May 16, 2020·Infectious Agents and Cancer·Mehrdad DavarmaneshMohammad Javad Gharavi
Nov 25, 2020·Journal of Medical Virology·Shuo LiBing Mei
Aug 31, 2021·International Journal of Cancer. Journal International Du Cancer·Sofia SaltaCarmen Jerónimo

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Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

SPSS Statistics for Mac
Seegene
Globocan
CLEOPATRE

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