High-risk human papillomavirus infection of the genital tract of women with a previous history or current high-grade vulvar intraepithelial neoplasia

Journal of Medical Virology
Frederic GoffinFrançois Coutlée

Abstract

Human papillomavirus (HPV) infection is associated with high-grade vulvar intraepithelial neoplasia (VIN-3). The prevalence of anogenital HPV infection in women with previously treated VIN-3 has not been documented yet. This cross-sectional study compared high-risk HPV DNA detection rates in women with past (n = 30) and current (n = 22) VIN-3 to those without current or past VIN (n = 86). HPV DNA was detected in vulvar and cervical samples with Hybrid Capture 2 (HC-2). Smoking was associated in multivariate analysis with current VIN-3 (odds ratio (OR) 8.3, 95% confidence interval (CI) 2.0-8.2) and any VIN-3 history (OR 6.5, 95% CI 2.5-16.5). High-risk HPV DNA was found on the vulva of 64%, 33%, and 20% of women with current VIN-3, past VIN-3, and without previous or current VIN, respectively. After controlling for age and smoking, high-risk HPV vulvar infection was associated with cervical high-risk HPV infection (OR 8.6, 95% CI 2.8-26.5; P = 0.001). After controlling for age, HPV infection was more often multifocal in women with current VIN-3 compared to women with previous but no current VIN-3 lesion (OR 17.6, 95% CI 1.4-227.2). Multifocal vulvar HPV infection was detected in women with previous or active VIN-3. Longitudinal ...Continue Reading

References

Jan 23, 1991·JAMA : the Journal of the American Medical Association·H M BauerM M Manos
Aug 1, 1991·The American Journal of Dermatopathology·E J WilkinsonR H Kaufman
May 1, 1995·Obstetrics and Gynecology·B J MonkS P Wilczynski
Jan 1, 1995·Gynecologic Oncology·R H Kaufman
Jan 1, 1996·Obstetrics and Gynecology·C L TrimbleR J Kurman
May 1, 1996·British Journal of Obstetrics and Gynaecology·J J HerodD M Luesley
Jan 1, 1996·International Journal of STD & AIDS·S JebakumarM N Bhattacharyya
Feb 1, 1996·Current Opinion in Obstetrics & Gynecology·R A Lininger, F A Tavassoli
Feb 1, 1997·Current Opinion in Obstetrics & Gynecology·C P CrumG L Mutter
Oct 23, 1997·Journal of the National Cancer Institute·M M MadeleineD A Galloway
Feb 25, 1998·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M van BeurdenJ ter Schegget
Sep 21, 2001·Best Practice & Research. Clinical Obstetrics & Gynaecology·F H Gastrell, D T McConnell
Dec 26, 2001·Gynecologic Oncology·A Al-GhamdiC B Gilks
Jan 5, 2002·Obstetrics and Gynecology Clinics of North America·R J CardosiM S Hoffman

❮ Previous
Next ❯

Citations

Jan 21, 2010·Cancer Causes & Control : CCC·Michele C GornickVictor Moreno
Sep 29, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Fani KokkaAdam N Rosenthal
Aug 5, 2009·Sexually Transmitted Diseases·Christine VelicerAlfred Saah
Mar 11, 2009·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A M KhanA Singer
Oct 5, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V LavouéK Morcel
Apr 15, 2008·Critical Reviews in Oncology/hematology·H P van de NieuwenhofJ A de Hullu
Dec 7, 2007·Gynécologie, obstétrique & fertilité·G AkermanR Rouzier
May 24, 2008·International Journal of Cancer. Journal International Du Cancer·Lindy A M SantegoetsLeen J Blok
Jul 27, 2010·International Journal of Cancer. Journal International Du Cancer·Annelinde TerlouLeen J Blok
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Annelinde TerlouLeen J Blok
Nov 30, 2012·Histopathology·Marta Del PinoJaume Ordi
Oct 24, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·J LaiJ Poole
Nov 22, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Edith M G van EschMariëtte I E van Poelgeest
May 2, 2007·International Journal of Cancer. Journal International Du Cancer·Lindy A M SantegoetsLeen J Blok
Mar 24, 2009·Obstetrics and Gynecology·Jennifer S SmithJeanne M Pimenta
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ursula WintersHenry C Kitchener

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.