High Risk Human Papillomavirus Infection of the Foreskin in Asymptomatic Men and Patients with Phimosis

The Journal of Urology
Larissa A AfonsoSílvia M B Cavalcanti

Abstract

There has been increasing interest in understanding the natural history of HPV and the diseases that it causes in men. HPV infection is strongly associated with penile cancer, lack of neonatal circumcision and phimosis. We investigated the incidence of HPV infection in asymptomatic men and patients with phimosis. We assessed 110 asymptomatic men and 30 patients who underwent circumcision due to phimosis. DNA was extracted from swabbed samples collected from asymptomatic men and from foreskin samples collected at circumcision. Polymerase chain reaction using consensus primers for detecting HPV-MY09/11 was performed to detect generic HPV DNA. HPV genotyping was done by polymerase chain reaction amplification with primers for the E6 gene DNA sequences HPV6, HPV11, HPV16, HPV18, HPV31, HPV33, HPV35, HPV45 and HPV58. HPV was present in 46.66% of patients with phimosis, of whom 50% had high risk HPV genotypes. Of asymptomatic cases 16.36% were HPV positive but only 1 sample showed high risk HPV. We detected a significantly high rate of HPV genital infection in patients presenting with phimosis compared with asymptomatic men (p = 0.00167). The prevalence of high risk HPV genotypes in patients with phimosis was also statistically signi...Continue Reading

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Citations

Jan 27, 2017·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Antonio Augusto Ornellas, Paulo Ornellas
Apr 14, 2017·Journal of Medical Virology·Larissa Alves AfonsoSilvia Maria Baeta Cavalcanti
Jun 28, 2018·PloS One·Lyriane Apolinário de AraújoMegmar Aparecida Dos Santos Carneiro
Sep 27, 2019·Frontiers in Cellular and Infection Microbiology·Yunying ZhouYunshan Wang
Feb 23, 2020·PloS One·Verônica ColpaniEliana Márcia Wendland
Sep 10, 2019·Journal of Evidence-based Medicine·Brian J MorrisJohn N Krieger

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