High-Risk Leukemia: Past, Present, and Future Role of NK Cells

Journal of Immunology Research
Melissa Mavers, Alice Bertaina

Abstract

Natural killer (NK) cells are a population of cytotoxic innate lymphocytes that evolved prior to their adaptive counterparts and constitute one of the first lines of defense against infected/mutated cells. Several studies have shown that in patients with acute leukemia given haploidentical hematopoietic stem cell transplantation, donor-derived NK cells play a key role in the eradication of cancer cells. The antileukemic effect is mostly related to the presence of "alloreactive" NK cells, that is, mature KIR+ NK cells that express inhibitory KIR mismatched with HLA class I (KIR-L) of the patient. A genotypic analysis detecting KIR B haplotype and the relative B content is an additional donor selection criterion. These data provided the rationale for implementing phase I/II clinical trials of adoptive infusion of either selected or ex vivo-activated NK cells, often from an HLA-mismatched donor. In this review, we provide a historical perspective on the role played by NK cells in patients with acute leukemia, focusing also on the various approaches to adoptive NK cell therapy and the unresolved issues therein. In addition, we outline new methods to enhance NK activity, including anti-KIR monoclonal antibody, bi-/trispecific antibo...Continue Reading

References

Sep 1, 1987·Transplantation·R Korngold, J Sprent
Nov 6, 2004·Blood Cells, Molecules & Diseases·Ulrike KoehlDirk Schwabe
Apr 28, 2006·The New England Journal of Medicine·Edward A Copelan
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eliane Gluckman
Nov 15, 2006·Immunological Reviews·Yenan T BrycesonEric O Long
Apr 18, 2007·Nature Reviews. Immunology·Warren D Shlomchik
Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph H ChewningBo Dupont
Dec 18, 2007·Bone Marrow Transplantation·V Rocha, F Locatelli
Sep 2, 2008·Immunological Reviews·Eric O Long
Nov 13, 2008·Seminars in Immunopathology·Andrea VelardiUNKNOWN Immunobiology Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Mar 14, 2009·Trends in Immunology·Petter BrodinPetter Höglund
Oct 3, 2009·British Journal of Haematology·Franco Locatelli
Dec 24, 2009·Immunology·Derek Middleton, Faviel Gonzelez
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey E RubnitzWing Leung
Mar 2, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David A RizzieriNelson J Chao
May 11, 2011·FEBS Letters·Lorenzo MorettaAlessandro Moretta
Aug 31, 2012·The New England Journal of Medicine·Jeffrey M VenstromKatharine C Hsu
Dec 5, 2012·Seminars in Oncology·Rupert Handgretinger
May 22, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andres WiernikJeffrey S Miller
Oct 8, 2013·Journal of Leukocyte Biology·Franco LocatelliSergio Rutella
Dec 24, 2013·Immunology Letters·Francesca BelloraCristina Bottino
Feb 15, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Inpyo ChoiKyoo-Hyung Lee

❮ Previous
Next ❯

Citations

Sep 4, 2019·The Journal of Clinical Investigation·Jonathan J HodginsMichele Ardolino
Oct 17, 2019·Cancers·Sooyeon OhSang-Woon Choi
Oct 10, 2018·Frontiers in Immunology·Dorian StolkMark A Exley
Mar 3, 2020·Frontiers in Immunology·Susanne H C BaumeisterRizwan Romee
Sep 4, 2020·Cellular & Molecular Immunology·Jezabel VaradéÁfrica González-Fernández
Feb 23, 2020·Frontiers in Immunology·Ece Canan SayitogluAdil Doganay Duru
Jun 2, 2020·Frontiers in Immunology·Aline PfefferleKarl-Johan Malmberg
Jul 18, 2019·International Journal of Molecular Sciences·Monika HolubovaDaniel Lysak
Apr 23, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Wei Zuo, Xiangyu Zhao
Aug 8, 2021·Cells·Joanna Dębska-ZielkowskaKatarzyna Stefańska

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
MDS
xenograft
genetic modification

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.