High-risk multimorbidity patterns on the road to cardiovascular mortality

BMC Medicine
Nils HaugPeter Klimek

Abstract

Multimorbidity, the co-occurrence of two or more diseases in one patient, is a frequent phenomenon. Understanding how different diseases condition each other over the lifetime of a patient could significantly contribute to personalised prevention efforts. However, most of our current knowledge on the long-term development of the health of patients (their disease trajectories) is either confined to narrow time spans or specific (sets of) diseases. Here, we aim to identify decisive events that potentially determine the future disease progression of patients. Health states of patients are described by algorithmically identified multimorbidity patterns (groups of included or excluded diseases) in a population-wide analysis of 9,000,000 patient histories of hospital diagnoses observed over 17 years. Over time, patients might acquire new diagnoses that change their health state; they describe a disease trajectory. We measure the age- and sex-specific risks for patients that they will acquire certain sets of diseases in the future depending on their current health state. In the present analysis, the population is described by a set of 132 different multimorbidity patterns. For elderly patients, we find 3 groups of multimorbidity patte...Continue Reading

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Citations

Aug 10, 2020·Mechanisms of Ageing and Development·Abdelaali HassaineKazem Rahimi
May 1, 2021·Journal of Personalized Medicine·Michael LeutnerAlexandra Kautzky-Willer
Aug 14, 2021·Scientific Reports·Furqan AzizGeorgios V Gkoutos

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