High risk of hypopituitarism after traumatic brain injury: a prospective investigation of anterior pituitary function in the acute phase and 12 months after trauma

The Journal of Clinical Endocrinology and Metabolism
F TanriverdiF Kelestimur

Abstract

Recent data have demonstrated that traumatic brain injury (TBI)-mediated hypopituitarism could be more frequent than previously known. However, most previous data were obtained from retrospective studies. The aim of this study was to determine 1) the prevalence of anterior pituitary hormone deficiencies in the acute phase of TBI and after 12 months, 2) whether severity of trauma correlated with basal hormone levels, and 3) whether initial hormone deficiencies predicted medium-term hormonal status. Fifty-two TBI patients (43 men and nine women) were included in the prospective study. Pituitary function was evaluated within 24 h of admission and after 1 yr. Some 5.8% of the patients had TSH deficiency, 41.6% had gonadotropin deficiency, 9.8% had ACTH deficiency, and 20.4% had GH deficiency (GHD). Twelve months after TBI, 5.8% had TSH deficiency, 7.7% had gonadotropin deficiency, 19.2% had ACTH deficiency, and 37.7% had GHD. Twenty-six patients (50.9%) had at least one anterior pituitary hormone deficiency, 21 patients (41.2%) had isolated hormone deficiencies, and five patients (9.7%) had combined hormone deficiencies. Overall, the pituitary hormone deficiencies recovered in 30 (57.7%) patients after 1 yr, and new pituitary hormo...Continue Reading

Citations

Dec 20, 2007·Intensive Care Medicine·Marc VinclairJean-François Payen
May 16, 2008·Pituitary·Joshua R DusickDaniel F Kelly
Jun 8, 2010·Pituitary·Valentina GascoGianluca Aimaretti
Nov 8, 2011·Pituitary·Susan R Rose, Bethany A Auble
Aug 6, 2010·Journal of Neurotrauma·Rebecca Jane MoonJustin Huw Davies
Oct 14, 2011·Journal of Neurotrauma·Odile Kozlowski MoreauMarc Rousseaux
Jan 18, 2013·Journal of Neurotrauma·Odile Kozlowski MoreauMarc Rousseaux
Jul 17, 2007·Current Opinion in Pediatrics·Silvia Einaudi, Claudia Bondone
Feb 7, 2008·Hormone Research·Lucy Ann Behan, Amar Agha
Sep 28, 2012·Sports Health·Cassidy M Foley, David H Wang
Nov 3, 2011·Neurosurgical Focus·Julie Dubourg, Mahmoud Messerer
Mar 30, 2007·Journal of Endocrinological Investigation·F TanriverdiF Kelestimur
Aug 29, 2013·Journal of Neurotrauma·Anna KopczakManfred Schneider
Sep 14, 2013·Journal of Neurotrauma·Bethany A AubleSusan R Rose
Sep 17, 2013·European Journal of Endocrinology·K BlijdorpS J C M M Neggers
Jul 2, 2008·Journal of Endocrinological Investigation·F TanriverdiF Kelestimur
Oct 29, 2010·European Journal of Endocrinology·A KopczakM Schneider
Jun 8, 2011·European Journal of Endocrinology·N E KokshoornA M Pereira
Dec 11, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Halil UlutabancaFahrettin Kelestimur
Feb 26, 2013·World Neurosurgery·Viraat HarshAnil Kumar
Feb 28, 2009·Journal of Endocrinological Investigation·A De BellisA Bellastella
Aug 12, 2014·Journal of Endocrinological Investigation·Y SimsekF Kelestimur
May 18, 2010·Journal of Women's Health·Angela ColantonioNora Cullen
Jan 1, 2014·Journal of Clinical Medicine·Mark J Hannon, Christopher J Thompson
Aug 20, 2015·Journal of Clinical Medicine·Kent ReifschneiderSusan R Rose
Aug 5, 2015·Journal of Clinical Medicine·Robert A Scranton, David S Baskin
Aug 5, 2015·Journal of Clinical Medicine·Fatih Tanriverdi, Fahrettin Kelestimur
Aug 5, 2015·Journal of Clinical Medicine·Marianne Klose, Ulla Feldt-Rasmussen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.