High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndrome

The Journal of Clinical Endocrinology and Metabolism
Marko StojanovicVera Popovic

Abstract

Hemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses, is a severe systemic infection, with acute shock, vascular leakage, hypotension, and acute renal failure. Pituitary ischemia/infarction and necrosis are known causes of hypopituitarism, often remaining unrecognized due to subtle clinical manifestations. Cases of hypopituitarism after HFRS were previously only sporadically reported. The aim of this study was to determine, for the first time, the prevalence of hypopituitarism among HFRS survivors. In 60 adults (aged 35.8+/-1.3 yr) who recovered from HFRS 3.7 +/- 0.5 yr ago (median 2 yr), assessment of serum T(4), free T(4), TSH, IGF-I, prolactin, cortisol, and testosterone (in males) was followed by insulin tolerance test and/or GHRH+GH-releasing peptide-6 stimulation tests. Severe GH deficiency was confirmed in eight of 60 patients (13.3%): in five with multiple pituitary hormone deficiencies (MPHDs) and isolated in three. Thyroid axis deficiency was confirmed in five of 60 patients (8.3%), all with MPHD. Hypothalamus-pituitary-adrenal axis deficiency was observed in six of 60 (10.0%); in five with MPHD and isolated in one. Gonadal axis deficiency was confirmed in seven of 56 male subjects (12.5%): five with MP...Continue Reading

References

Jul 1, 1992·Journal of Internal Medicine·T ForslundM Poutiainen
May 1, 1990·The Journal of Infectious Diseases·L B Chen, W S Yang
Dec 1, 1994·Australian and New Zealand Journal of Medicine·E Wallace, I M Holdaway
Jan 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J LarranagaF C Whittier
Mar 1, 1995·Clinical Immunology and Immunopathology·O A AlexeyevA S Mishukov
Jun 9, 1994·The New England Journal of Medicine·M L Vance
Jan 1, 1995·Scandinavian Journal of Infectious Diseases·M ValtonenM Brummer-Korvenkontio
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J J BugertG Darai
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Mark L HartmanUNKNOWN U.S. HypoCCS Study Group
Jun 13, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timo HautalaHeikki Kauma
Feb 14, 2003·Lancet·Kalman Kovacs
Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E AlgünH Aksoy
Jan 1, 1953·Annals of Internal Medicine·R L HULLINGHORST, A STEER
May 1, 1954·The American Journal of Medicine·R J LUKES
May 13, 2005·Endocrine·Sandra PekicVera Popovic
Nov 4, 2005·Journal of the American Society of Nephrology : JASN·Walter MuranyiFokko J van der Woude
May 19, 2006·Emerging Infectious Diseases·Anna PapaAntonis Antoniadis

❮ Previous
Next ❯

Citations

Apr 17, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S MäkeläJ Mustonen
Jan 1, 2009·BMJ Case Reports·Christina JostKurt Weber
Mar 14, 2009·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Dragan JovanovićJelena Tadić
Jul 24, 2015·Clinical Endocrinology·Terhi PartanenTimo Hautala
Jul 20, 2011·Clinical Endocrinology·Fatih Kilicliİlyas Dokmetas
May 5, 2012·Critical Reviews in Microbiology·Maria SargianouGeorge Panos
Mar 5, 2017·European Journal of Endocrinology·Sandra Pekic, Vera Popovic
Nov 20, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Marlene TarvainenPia Jaatinen
Feb 3, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Luiz Eduardo Armondi WildembergMônica Roberto Gadelha
Jul 5, 2012·Reviews in Medical Virology·Antti VaheriOlli Vapalahti
Sep 17, 2020·Journal of Clinical Immunology·Terhi PartanenTimo Hautala
Apr 13, 2019·Viruses·Soerajja BhoelanMarco Goeijenbier
Oct 1, 2020·BMC Infectious Diseases·Sebastian SchwabPhilipp Lutz
Aug 5, 2021·Experimental and Therapeutic Medicine·Gabriela LupuşoruGener Ismail

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
S MäkeläJ Mustonen
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Tatjana Avsic-ZupancAke Lundkvist
Scandinavian Journal of Infectious Diseases
M ValtonenM Brummer-Korvenkontio
Journal of Internal Medicine
T ForslundM Poutiainen
© 2022 Meta ULC. All rights reserved