High risk of recurrent venous thrombosis in patients with lower-leg cast immobilization

Journal of Thrombosis and Haemostasis : JTH
B NemethS C Cannegieter

Abstract

Essentials The risk of recurrent venous thrombosis (VT) after leg-cast in patients with prior VT is unknown. In a nested case-control study within the MEGA follow-up study we aimed to estimate this risk. Patients with a history of VT who require lower-leg cast have a 4.5-fold risk for recurrence. This relative risk translates to an absolute risk for recurrent VT of about 3.2% within 3 months. SUMMARY: Background Patients with lower-leg cast immobilization have a substantially increased risk of developing a first venous thrombosis (VT), whereas the risk in patients with a history of VT is as yet unknown. Aims To estimate the risk of recurrent VT after lower-leg cast immobilization in patients with a history of VT. Methods A case-control study nested within a cohort of 4597 patients with a first VT who were followed over time for recurrence from 1999 to 2010 (MEGA follow-up study). Participants completed a questionnaire on risk factors for recurrent thrombosis, including having a cast in the first 3 months before a recurrence (cases) or a random 3-month period during follow-up for participants without recurrence (controls). In total, 2723/4597 (59%) participants returned the questionnaire. Odds ratios (ORs), adjusted for age and ...Continue Reading

References

Feb 11, 2005·JAMA : the Journal of the American Medical Association·Jeanet W BlomFrits R Rosendaal
Mar 21, 2007·Journal of Thrombosis and Haemostasis : JTH·I A NaessJ Hammerstrøm
Aug 27, 2010·Journal of Thrombosis and Haemostasis : JTH·S C ChristiansenS C Cannegieter
Dec 7, 2010·Lancet·Paul Alexander KyrleSabine Eichinger
Mar 15, 2012·Chest·Gordon H GuyattUNKNOWN American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·S C Cannegieter, A van Hylckama Vlieg
Jul 22, 2014·Journal of Thrombosis and Haemostasis : JTH·R A van AdrichemS C Cannegieter
Aug 14, 2015·Journal of Thrombosis and Haemostasis : JTH·J F TimpS C Cannegieter
Dec 14, 2016·The New England Journal of Medicine·Raymond A van AdrichemUNKNOWN POT-KAST and POT-CAST Group

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Citations

Mar 27, 2020·Research and Practice in Thrombosis and Haemostasis·Susan R Kahn, Sudeep Shivakumar
Oct 19, 2019·Journal of Thrombosis and Thrombolysis·Hannah C PuhrSabine Eichinger
Dec 31, 2020·TH Open : Companion Journal to Thrombosis and Haemostasis·Jeffrey I WeitzPeter Verhamme

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