High risk of rhabdomyolysis and acute kidney injury after traumatic limb compartment syndrome

Annals of Plastic Surgery
Wei-Hsuan TsaiYen-Yi Ho

Abstract

Rhabdomyolysis often occurs after traumatic compartment syndrome, and high morbidity and mortality have been reported with the acute kidney injury that develops subsequently. We focused on the risk factors for rhabdomyolysis and acute kidney injury in patients with traumatic compartment syndrome. We also analyzed the relation between renal function and rhabdomyolysis in these patients. A retrospective chart review was conducted from January 2006 to March 2012. Inpatients with traumatic compartment syndrome were included. We evaluated patients' demographics, history of illicit drugs use or alcohol consumption, mechanism of injury, symptoms, serum creatine kinase levels, and kidney function. A total of 52 patients with a mean age of 40.9 years were included; 23 patients had rhabdomyolysis (44.2%), of which 9 patients developed acute kidney injury (39.1%). Significant predictive factors for rhabdomyolysis were history of illicit drugs or alcohol use (P=0.039; odds ratio, 5.91) and ischemic injury (P=0.005). We found a moderate correlation between serum creatine kinase levels and serum creatinine levels (R=0.57; P<0.0001). The correlation coefficient (R) between serum creatine kinase levels and the estimated creatinine clearance ra...Continue Reading

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Citations

Oct 11, 2016·International Journal of Critical Illness and Injury Science·Loreto Lollo, Andreas Grabinsky
May 17, 2018·Trauma Surgery & Acute Care Open·Jennifer Cone, Kenji Inaba
Jun 4, 2019·Pediatric Emergency Care·Michael GottliebTrevor Landas
Jan 7, 2019·BMC Musculoskeletal Disorders·Abraham NilssonJörg Schilcher
Nov 7, 2020·Physical Therapy·Jian ChenHui Pan

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