High risk of transfusion-induced alloimmunization of patients with inflammatory bowel disease

The American Journal of Medicine
Pavol PapayGünther F Körmöczi

Abstract

Anemia is highly prevalent in inflammatory bowel disease patients, and red blood cell transfusion is often indicated already at reproductive age. Both transfusion and pregnancy may induce red cell alloantibodies, potentially complicating further transfusions and pregnancies. As recent evidence suggests that inflammation may promote red cell antibody induction, the alloimmunization risk of these patients after allogenic erythrocyte exposure was investigated. Red cell alloantibody status and clinical data were analyzed in 193 inflammatory bowel disease patients with a history of transfusion or pregnancy, and compared with transfused controls with noninflammatory diseases (n=357). In transfused patients with inflammatory bowel disease, a 2.5-fold-increased red cell antibody prevalence was found (10/119, 8.4%), compared with transfused sex-matched controls with noninflammatory diseases (12/357, 3.4%; P=.023). Patients with inflammatory bowel disease had fewer transfusions (mean 3.0 vs 4.2, P=.003) but higher C-reactive protein levels during transfusion than controls (mean 8.4 vs 5.4 mg/dL, P <.001). The red cell antibodies of inflammatory bowel disease patients were clinically significant, directed against different Rh, Kell, Duffy...Continue Reading

References

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Citations

Jun 15, 2014·Transfusion Medicine Reviews·Jeanne E HendricksonBeth H Shaz
Oct 13, 2015·British Journal of Haematology·Alex B RyderChristopher A Tormey
Apr 27, 2016·Hematology/oncology Clinics of North America·Jeanne E Hendrickson, Christopher A Tormey
Jun 21, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·David R GibbJeanne E Hendrickson
May 31, 2018·Transfusion Medicine·E G da Cunha GomesJ F N Neto
Feb 28, 2019·Blood·Christopher A Tormey, Jeanne E Hendrickson
Dec 4, 2016·Hematology·Jeanne E Hendrickson, Christopher A Tormey
Dec 7, 2018·Frontiers in Immunology·Seema R PatelSean R Stowell
Apr 21, 2018·British Journal of Haematology·Matthew S KarafinUNKNOWN NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III)

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