High-risk papillomavirus infection is associated with altered antibody responses in genital tract: non-specific responses in HPV infection

Viral Immunology
E BardEstelle Seilles

Abstract

In order to gain more information about local humoral immune responses to HPV infection, we quantified IgG, IgM, secretory-IgA (S-IgA), and total-IgA by ELISA, and lysozyme and lactoferrin by TR-IFMA, in cervical and cervicovaginal secretions of 40 healthy women and 28 high-risk HPV infected patients (11 were HPV16+). IgG, total-IgA, and S-IgA concentrations in cervicovaginal secretions (p < 0.0001) and high IgG and total-IgA concentrations (p < 0.001 and p < 0.01, respectively) in endocervical secretions were significantly higher in HPV+ patients than in the healthy group. Since the S-IgA/total-IgA ratio was significantly lower in cervicovaginal (7.5%) and endocervical secretions (36.5%) in HPV+ women compared to the control group (p < 0.003 and p < 0.001, respectively), HPV could be responsible for an increase in local production of non-secretory IgA (monomeric and dimeric forms). IgG and total-IgA concentrations in cervicovaginal and endocervical secretions fell in the same general percentage range in both HPV16+ and HPV+ groups (80% and 15%, respectively). However, the S-IgA/total-IgA ratio was much lower in HPV16+ than in HPV+ women, in both cervicovaginal secretions (3.4%) (p < 0.003) and in endocervical secretions (23.3%...Continue Reading

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Citations

Nov 15, 2012·Human Vaccines & Immunotherapeutics·Mirte ScherpenisseFiona R M van der Klis
Aug 8, 2006·Clinical Pediatrics·Michael E Pichichero
May 12, 2007·Expert Review of Anticancer Therapy·Gianna Badaracco, Aldo Venuti
Apr 20, 2007·The Journal of Obstetrics and Gynaecology Research·Bor-Ching SheuSu-Cheng Huang
Nov 14, 2007·European Journal of Gastroenterology & Hepatology·Tian-You MaJian-Wu Zheng
Aug 5, 2016·Journal of Lower Genital Tract Disease·Barbara GardellaArsenio Spinillo
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Héla SaidiLaurent Belec

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