High-Risk Sarcoidosis. Current Concepts and Research Imperatives

Annals of the American Thoracic Society
William H SauerWalter Royal

Abstract

Sarcoidosis is a disease with heterogeneous manifestations and outcomes, varying in part on the basis of organ involvement. Specifically, patients with sarcoidosis at risk for poor outcomes include individuals with treatment-resistant pulmonary sarcoidosis, including fibrotic pulmonary disease and pulmonary hypertension, as well as those with cardiac, neurologic, and multiorgan disease. The limited but available data relating to these patients with high-risk sarcoidosis, defined as those patients with presentations requiring medical intervention to avoid progressive disability or premature death, was evaluated as part of the National Heart, Lung, and Blood Institute's workshop to improve understanding of these disease manifestations. In particular, knowledge gaps that preclude a greater understanding of the pathogenesis and management of these severe sarcoidosis clinical phenotypes were identified in the workshop. Research strategies are proposed to address critical knowledge gaps that would further our understanding of these disease manifestations and enhance the care of these patients.

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Citations

Jul 14, 2018·Current Opinion in Pulmonary Medicine·Peter Korsten, Marjolein Drent
Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
Aug 11, 2020·Seminars in Respiratory and Critical Care Medicine·Marina Dornfeld Cunha Castro, Carlos Alberto de Castro Pereira
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Jan 16, 2021·Breathe·Katrin Mannes, Paul S Thomas
Sep 16, 2021·Annals of the American Thoracic Society·David M PerlmanManeesh Bhargava

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Methods Mentioned

BETA
biopsies
X-ray
imaging techniques
biopsy

Clinical Trials Mentioned

NCT03260556

Software Mentioned

GRADS
ACCESS

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