High salt diets dose-dependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells

International Journal of Cancer. Journal International Du Cancer
Sosuke KatoMasae Tatematsu

Abstract

Intake of salt and salty food is known as a risk factor for gastric carcinogenesis. To examine the dose-dependence and the mechanisms underlying enhancing effects, Mongolian gerbils were treated with N-methyl-N-nitrosourea (MNU), Helicobacter pylori and food containing various concentrations of salt, and were sacrificed after 50 weeks. Among gerbils treated with MNU and H. pylori, the incidences of glandular stomach cancers were 15% in the normal diet group and 33%, 36% and 63% in the 2.5%, 5% and 10% NaCl diet groups, showing dose-dependent increase (p < 0.01). Intermittent intragastric injection of saturated NaCl solution, in contrast, did not promote gastric carcinogenesis. In gerbils infected with H. pylori, a high salt diet was associated with elevation of anti-H. pylori antibody titers, serum gastrin levels and inflammatory cell infiltration in a dose-dependent fashion. Ten percent NaCl diet upregulated the amount of surface mucous cell mucin (p < 0.05), suitable for H. pylori colonization, despite no increment of MUC5AC mRNA, while H. pylori infection itself had an opposing effect, stimulating transcription of MUC6 and increasing the amount of gland mucous cell mucin (GMCM). High salt diet, in turn, decreased the amount ...Continue Reading

References

May 1, 1991·Cancer Causes & Control : CCC·S TsuganeS Watanabe
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Dec 1, 1994·Analytical Biochemistry·Y Goso, K Hotta
Jan 1, 1995·The American Journal of Surgical Pathology·E MatyjaM Zabek
May 1, 1994·Japanese Journal of Cancer Research : Gann·S TsuganeK Sugano
Jan 1, 1996·Cancer Causes & Control : CCC·S Kono, T Hirohata
Sep 15, 2001·The New England Journal of Medicine·N UemuraR J Schlemper
Nov 21, 2002·Journal of the National Cancer Institute·Céu FigueiredoManuel Sobrinho-Simões

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Citations

Nov 1, 2012·Seminars in Immunopathology·Tetsuya TsukamotoMasae Tatematsu
Aug 7, 2009·Human Genetics·Anya N MilneG J A Offerhaus
Jan 24, 2007·Journal of Gastroenterology·Masae TatematsuTakeshi Toyoda
Sep 29, 2012·Japanese Journal of Clinical Oncology·Mototsugu Kato, Masahiro Asaka
Oct 12, 2010·Clinical Microbiology Reviews·Lydia E WroblewskiKeith T Wilson
Apr 10, 2013·Infection and Immunity·Jennifer A GaddyTimothy L Cover
May 14, 2009·World Journal of Gastroenterology : WJG·Xiao-Qin WangHong Yan
Apr 30, 2011·World Journal of Gastroenterology : WJG·Wan-Guang YangTong-Wen Sun
Jul 16, 2013·Journal of Global Infectious Diseases·Rahul S MhaskarKwa Boo
Jun 13, 2012·Journal of Biomedicine & Biotechnology·Kawiya SintaraNaruemon Klaikeaw
Aug 15, 2014·Journal of Clinical Biochemistry and Nutrition·Masato TamuraIchinosuke Hyodo
May 6, 2008·Nutrition Reviews·Chun Liu, Robert M Russell
Oct 20, 2015·Journal of Epidemiology·Mitsumasa UmesawaUNKNOWN JACC Study Group
Oct 11, 2007·Helicobacter·Shin Maeda, Andreas F Mentis
Aug 31, 2013·Gut Microbes·Timothy L Cover, Richard M Peek
Aug 22, 2013·Gut Microbes·Alexander Sheh, James G Fox
Jul 27, 2007·Toxicologic Pathology·Tetsuya TsukamotoMasae Tatematsu
Aug 5, 2017·International Journal of Molecular Sciences·Tetsuya TsukamotoXueyuan Cao
Jul 9, 2014·Nature Reviews. Gastroenterology & Hepatology·Peter MalfertheinerMichael Selgrad
Feb 6, 2017·Disease Models & Mechanisms·Michael D BurkittD Mark Pritchard
Mar 23, 2011·International Journal of Cancer. Journal International Du Cancer·Masahiro TanakaHideto Takahashi
Oct 7, 2015·Infection and Immunity·John T LohTimothy L Cover
Jun 20, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Shoichiro Tsugane, Shizuka Sasazuki
Dec 17, 2014·Clinical Endoscopy·Jin Young ParkRolando Herrero
Apr 28, 2020·Nutrition and Cancer·Farhad Vahid, Sayed Hossein Davoodi
Feb 22, 2018·Immunology·Ralf Willebrand, Markus Kleinewietfeld
May 1, 2016·Porto Biomedical Journal·Catarina MonteiroBárbara Peleteiro
Oct 17, 2014·World Journal of Gastroenterology : WJG·Victor PasechnikovMarcis Leja
Nov 8, 2018·Experimental and Therapeutic Medicine·Muxiao ZhongYali Zhang
Feb 1, 2020·Journal of Clinical Biochemistry and Nutrition·Atsushi GotoIsao Sakaida
Jun 20, 2019·Frontiers in Immunology·Ralf WillebrandMarkus Kleinewietfeld
May 23, 2019·World Journal of Gastroenterology : WJG·Moon Kyung JooHoon Jai Chun
May 19, 2007·Cancer Research·John T LohTimothy L Cover
Feb 12, 2021·Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society·Payel ChakrabortyNachimuthu Senthil Kumar
Sep 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Maria LopesFernando Ramos

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