High-sensitivity C-reactive protein and left ventricular remodeling in patients with acute myocardial infarction

Heart and Vessels
Kohzou UeharaSusumu Ito

Abstract

Inflammatory cytokines are suspected to play an important role in the pathophysiology of left ventricular (LV) remodeling. We investigated whether high-sensitivity C-reactive protein (CRP) (hs-CRP) is a predictor for LV remodeling in patients with acute myocardial infarction (AMI) with successful reperfusion, and also whether such a situation can be avoided by the administration of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB). The subjects were 139 patients with an initial attack of anterior myocardial infarction successfully treated by reperfusion therapy. They were randomly divided into the following two groups: an angiotensin (AG) group (91 patients treated with ACEI/ARB) and a NON-AG group (48 patients not treated with ACEI/ARB). Levels of hs-CRP, creatine kinase, human atrial natriuretic polypeptide, brain natriuretic peptide (BNP), fasting blood glucose, serum lipids, fibrinogen, fibrin degradation product, prothromloin time, and activated partial thromboplastin time were measured immediately after 1, 2, 3, and 7 days, and 1 months after the onset of AMI. ACEI or ARB administration lowered hs-CRP levels and prevented the development of LV remodeling. Peak CRP levels significant...Continue Reading

Citations

Mar 27, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Iwona SwiatkiewiczJacek Kubica
Jul 19, 2005·Heart and Vessels·Masaya SugiyamaYasuaki Dohi
Jan 28, 2006·Heart and Vessels·Gokcen OrhanSerap Aykut Aka
Jan 15, 2013·Clinical Reviews in Allergy & Immunology·Yoav ArnsonHoward Amital
Dec 25, 2003·The American Journal of Medicine·James S Zebrack, Jeffrey L Anderson
Oct 1, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Toshiro KatayamaKatsusuke Yano
Apr 10, 2012·The American Journal of Cardiology·Marie FertinChristophe Bauters
Sep 17, 2005·Pharmacotherapy·Nigel J Dagenais, Fakhreddin Jamali
Mar 30, 2010·The American Journal of Cardiology·Adelaide M Arruda-OlsonVéronique L Roger
May 16, 2006·The American Journal of Cardiology·Barry GreenbergBertram Pitt
Jan 27, 2004·The Annals of Pharmacotherapy·James M BackesPatrick M Moriarty

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.