High-sensitivity C-reactive protein does not improve the differential diagnosis of HNF1A-MODY and familial young-onset type 2 diabetes: A grey zone analysis

Diabetes & Metabolism
Christine Bellanné-ChantelotMonogenic Diabetes Study Group of the Société Francophone du Diabète (SFD)

Abstract

Low plasma levels of high-sensitivity C-reactive protein (hs-CRP) have been suggested to differentiate hepatocyte nuclear factor 1 alpha-maturity-onset diabetes of the young (HNF1A-MODY) from type 2 diabetes (T2D). Yet, differential diagnosis of HNF1A-MODY and familial young-onset type 2 diabetes (F-YT2D) remains a difficult challenge. Thus, this study assessed the added value of hs-CRP to distinguish between the two conditions. This prospective multicentre study included 143 HNF1A-MODY patients, 310 patients with a clinical history suggestive of HNF1A-MODY, but not confirmed genetically (F-YT2D), and 215 patients with T2D. The ability of models, including clinical characteristics and hs-CRP to predict HNF1A-MODY was analyzed, using the area of the receiver operating characteristic (AUROC) curve, and a grey zone approach was used to evaluate these models in clinical practice. Median hs-CRP values were lower in HNF1A-MODY (0.25mg/L) than in F-YT2D (1.14mg/L) and T2D (1.70mg/L) patients. Clinical parameters were sufficient to differentiate HNF1A-MODY from classical T2D (AUROC: 0.99). AUROC analyses to distinguish HNF1A-MODY from F-YT2D were 0.82 for clinical features and 0.87 after including hs-CRP. For the grey zone analysis, th...Continue Reading

References

Apr 26, 2003·International Journal of Epidemiology·Joël Coste, Jacques Pouchot
Nov 26, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·C CaretteC Bellanné-Chantelot
Jun 17, 2011·The Journal of Clinical Endocrinology and Metabolism·Christine Bellanné-ChantelotUNKNOWN French Monogenic Diabetes Study Group
Jun 28, 2011·Diabetes Care·Tim J McDonaldAndrew T Hattersley
Jun 19, 2013·The Journal of Clinical Endocrinology and Metabolism·Catherine PihokerUNKNOWN SEARCH for Diabetes in Youth Study Group
Aug 21, 2013·Diabetologia·Carolyn C RichardsonMichael R Christie
Feb 13, 2014·European Journal of Human Genetics : EJHG·Kevin ColcloughChristine Bellanné-Chantelot

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Citations

Apr 23, 2016·Canadian Journal of Diabetes·José TimsitChristine Bellanné-Chantelot
Oct 16, 2015·Current Diabetes Reports·Jeffrey W Kleinberger, Toni I Pollin
Sep 14, 2019·Endocrine Regulations·Terezia ValkovicovaDaniela Gasperikova
Jul 18, 2018·Frontiers in Endocrinology·Jana UrbanováJan Brož
Jul 25, 2019·Frontiers in Endocrinology·Paola de CandiaGiuseppe Matarese
Jun 13, 2020·Diabetology & Metabolic Syndrome·Renata Peixoto-BarbosaFernando M A Giuffrida

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