High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Richard NowakBertil Lindahl

Abstract

To describe the baseline, 1 hr and delta high sensitivity cardiac troponin (hs-cTnT) values in patients with suspected acute myocardial infarction (AMI) but without a final acute coronary syndrome (ACS) diagnosis. hs-cTnT assay for RAPID rule out of acute myocardial infarction (TRAPID-AMI) was a prospective diagnostic trial that enrolled emergency department (ED) patients with suspected AMI. Final patient diagnoses were adjudicated by a clinical events committee and subjects placed in different clinical groups: AMI, unstable angina, non-ACS cardiac, non-cardiac and unknown origin. The baseline, 1 hr and delta hs-cTnT values were analysed in the 902 non-ACS patients. Amongst the 1282 studied the patient groups were 213 (17%) AMI, 167 (13%) unstable angina, 113 (9%) non-ACS cardiac, 288 (22%) non-cardiac and 501 (39%) unknown origin. The hs-cTnT values in the non-cardiac and unknown origin groups were combined. The median hs-cTnT values (ng/L) were higher (p < 0.001) in the non-ACS cardiac compared to the non-cardiac/unknown origin group at baseline (11.8, <5) and 1 hr (12.3, <5). Their negative predictive values were 0.955 (baseline) and 0.954 (1 hr) for predicting non-ACS cardiac versus non-cardiac/unknown origin diagnoses. Hs-...Continue Reading

References

Oct 26, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·J E Hollander
Jan 20, 2005·Heart·S GoodacreJ Nicholl
Dec 21, 2005·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Charles V PollackJudd E Hollander
Jan 16, 2010·Annals of Emergency Medicine·Pamela L OwensRyan L Mutter
Oct 4, 2011·Clinical Chemistry·Fred S AppleUNKNOWN IFCC Task Force on Clinical Applications of Cardiac Biomarkers
Jun 23, 2012·European Heart Journal·Kristian ThygesenUNKNOWN Study Group on Biomarkers in Cardiology of ESC Working Group on Acute Cardiac Care
Aug 16, 2012·Archives of Internal Medicine·Tobias ReichlinChristian Mueller
May 15, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Richard BodyUNKNOWN TRAPID-AMI Investigators
Nov 5, 2016·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Stephen MeigherAdam J Singer

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