High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

European Journal of Preventive Cardiology
Liselotte W WijsmanSimon P Mooijaart

Abstract

Cardiac troponin T (cTnT), measured with a high-sensitivity (hs) assay, is associated with cognitive decline, but the underlying mechanism is unknown. We investigated the association of hs-cTnT with cognitive function and decline, and studied whether this association was independent of cardiovascular diseases or risk factors, and N-terminal pro-brain natriuretic peptide (NT-proBNP). We studied 5407 participants (mean age 75.31 years) from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), who all had cardiovascular diseases or risk factors thereof. Participants with pre-existent advanced clinical heart failure were excluded. Hs-cTnT and NT-proBNP obtained after 6 months of follow-up were related with cognitive function, tested repeatedly during a mean follow-up of 3.2 years. Participants with higher hs-cTnT performed worse at baseline on Stroop test (mean baseline score (standard error (SE)) lowest vs highest third 65.91 (1.16) vs 69.40 (1.10) seconds, p < 0.001), Letter-Digit Coding test (23.35 (0.32) vs 22.40 (0.31) digits coded, p < 0.001), immediate Picture-Word Learning test (9.45 (0.09) vs 9.31 (0.08) pictures remembered, p = 0.002) and delayed Picture-Word Learning test (10.33 (0.12) vs 10.10 (0.12) p...Continue Reading

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Citations

Oct 23, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Isabelle F van der VelpenBehnam Sabayan
Jun 30, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Marja G J VeugenCoen D A Stehouwer
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May 12, 2021·Stroke; a Journal of Cerebral Circulation·Bibek GyanwaliSaima Hilal

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