High-sensitivity cardiac troponin T: risk stratification tool in patients with symptoms of chest discomfort.

PloS One
Alma M MingelsLeonard Hofstra

Abstract

Recent studies have demonstrated the association between increased concentrations of high-sensitivity cardiac troponin T (hs-cTnT) and the incidence of myocardial infarction, heart failure, and mortality. However, most prognostic studies to date focus on the value of hs-cTnT in the elderly or general population. The value of hs-cTnT in symptomatic patients visiting the outpatient department remains unclear. The aim of this study was to investigate the prognostic value of hs-cTnT as a biomarker in patients with symptoms of chest discomfort suspected for coronary artery disease and to assess its additional value in combination with other risk stratification tools in predicting cardiac events. We studied 1,088 patients (follow-up 2.2 ± 0.8 years) with chest discomfort who underwent coronary calcium scoring and coronary CT-angiography. Traditional cardiovascular risk factors and concentrations of hs-cTnT, N-terminal pro-brain-type natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hsCRP) were assessed. Study endpoint was the occurrence of late coronary revascularization (>90 days), acute coronary syndrome, and cardiac mortality. Hs-cTnT was a significant predictor for the composite endpoint (highest quartile [...Continue Reading

Associated Clinical Trials

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Nov 22, 2013·QJM : Monthly Journal of the Association of Physicians·C J PetrieJ A Abed
Jun 15, 2014·BMC Cardiovascular Disorders·Anil VaidyaErik A L Biessen
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Apr 30, 2019·Angiology·Alparslan Kurtul, Ender Ornek

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

SPSS Statistics
Cardiac Comprehensive Analysis
Xcelera

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