High-Sensitivity Troponin I Levels and Coronary Artery Disease Severity, Progression, and Long-Term Outcomes

Journal of the American Heart Association
Ayman Samman TahhanArshed A Quyyumi

Abstract

The associations between high-sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear. We investigated whether there is an association between hsTnI and angiographic severity and progression of CAD and whether the predictive value of hsTnI level for incident cardiovascular outcomes is independent of CAD severity. In 3087 patients (aged 63±12 years, 64% men) undergoing cardiac catheterization without evidence of acute myocardial infarction, the severity of CAD was calculated by the number of major coronary arteries with ≥50% stenosis and the Gensini score. CAD progression was assessed in a subset of 717 patients who had undergone ≥2 coronary angiograms >3 months before enrollment. Patients were followed up for incident all-cause mortality and incident cardiovascular events. Of the total population, 11% had normal angiograms, 23% had nonobstructive CAD, 20% had 1-vessel CAD, 20% had 2-vessel CAD, and 26% had 3-vessel CAD. After adjusting for age, sex, race, body mass index, smoking, hypertension, diabetes mellitus history, and renal function, hsTnI levels were independently associated with the severity of CAD measured by the Gensini score (log 2 ß=0.31; 95% confidence interv...Continue Reading

References

Jul 1, 1988·Journal of the American College of Cardiology·J A AmbroseV Fuster
Aug 7, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·M S SuleimanG D Angelini
Nov 30, 2005·Archives of Internal Medicine·Peter W F WilsonChristopher J O'Donnell
Aug 30, 2008·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Jørgen JeppesenSten Madsbad
Jun 10, 2009·Circulation·Michael J PencinaRamachandran S Vasan
Mar 2, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Olaf SchulzAllan S Jaffe
Mar 20, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Eduard M LauferLeonard Hofstra
Jun 11, 2011·Journal of the American College of Cardiology·Harvey D White
Jun 17, 2011·The American Journal of Cardiology·Gjin NdrepepaAdnan Kastrati
Dec 29, 2011·JAMA : the Journal of the American Medical Association·Till KellerStefan Blankenberg
Oct 17, 2012·American Heart Journal·Ian J NeelandArshed A Quyyumi
Feb 19, 2013·Journal of the American College of Cardiology·Torbjørn OmlandUNKNOWN PEACE Investigators
Apr 11, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tar-Choon AwShiow-Pin Tan
Nov 26, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christoph SinningUNKNOWN Gutenberg Health Study
Aug 13, 2015·The New England Journal of Medicine·Brendan M EverettUNKNOWN BARI 2D Study Group
Dec 23, 2016·Journal of the American College of Cardiology·Ian FordNicholas L Mills

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Citations

Nov 7, 2018·Annals of Internal Medicine·Muhammad HammadahArshed A Quyyumi
Nov 21, 2018·Critical Reviews in Clinical Laboratory Sciences·Magnus Nakrem LyngbakkenTorbjørn Omland
Feb 16, 2019·British Journal of Clinical Pharmacology·Arintaya PhrommintikulNipon Chattipakorn
Jul 13, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Peter Uchenna AmadiChiamaka Winifred Adumekwe
May 20, 2020·Annals of Internal Medicine·Stephen P JuraschekKenneth J Mukamal
Sep 27, 2020·Biomolecules·Ibrahim T FazminKamalan Jeevaratnam
Oct 9, 2020·Arteriosclerosis, Thrombosis, and Vascular Biology·Ahmed AlBadriC Noel Bairey Merz
Jun 28, 2021·The American Journal of Cardiology·Welingson Vanucci Negreiros GuimarãesCarlos M Campos
Oct 19, 2021·Frontiers in Cardiovascular Medicine·Yuen-Kwun Wong, Hung-Fat Tse

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Datasets Mentioned

BETA
AG051633

Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

R
survIDINRI
survC1
SPSS Statistics

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