High-sensitivity troponin T in preterm infants with a hemodynamically significant patent ductus arteriosus

Journal of Perinatology : Official Journal of the California Perinatal Association
Priyanka AsraniSunil K Jain

Abstract

To investigate if a hemodynamically significant patent ductus arteriosus (hsPDA) leads to elevated high-sensitivity troponin T (hsTnT) and NTproBNP levels in serum. Infants <34 weeks and <1500 g were prospectively enrolled, except those with major congenital or chromosomal anomalies. An echocardiogram (ECHO) was performed and hsTnT and NTproBNP were measured within 5 days of life and repeated after treatment of hsPDA. Clinical, ECHO, and hsTnT data were analyzed using Student t-test, two proportion z-test, and regression analysis. Seventy infants were enrolled. Infants in the hsPDA group had lower gestation and birth weight. Mean hsTnT and NTproBNP levels in the hsPDA group were higher compared to the group without an hsPDA, with levels being 251.54 vs 161.6 pg/ml, p < 0.01 for hsTnT and 18181.02 vs 3149.23 pg/ml, p < 0.001 for NTproBNP. HsPDA leads to increased hsTnT and NTproBNP levels in preterm infants without affecting cardiac function.

References

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Citations

Sep 7, 2019·Pediatric Cardiology·Jonna KarlénCecilia Pegelow Halvorsen
Feb 23, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Yulia VaisbourdAmir Kugelman
Jan 8, 2021·Frontiers in Pediatrics·Flaminia BardanzelluVassilios Fanos
Apr 10, 2021·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Robert GodinDoron J Kahn
May 2, 2021·Pediatrics and Neonatology·Hsiao-Wen HuangReyin Lien
Nov 18, 2021·Pediatric Cardiology·Alan P WangAllan S Jaffe

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Methods Mentioned

BETA
X-ray
enzyme-linked immunosorbent assay
cesarean section

Software Mentioned

SPSS Statistics

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