High sensitivity with color duplex sonography in thrombosis screening after ankle fracture surgery

Journal of Thrombosis and Haemostasis : JTH
L LapidusStefan Rosfors

Abstract

Phlebography is regarded as the reference standard for diagnosing asymptomatic deep vein thrombosis (DVT) in studies of thromboprophylaxis. However, technical advances with noninvasive color duplex sonography (CDS) have made this procedure an interesting alternative. The objective of the present prospective study was to compare the sensitivity and specificity of CDS with those of phlebography. The first 180 consecutive patients included in a larger randomized trial for prolonged thromboprophylaxis were subject to unilateral CDS and to phlebography after ankle fracture surgery. The patients were examined 6 weeks after surgery, all examinations being evaluated blindly. After patient drop outs and exclusions, 144 patients were left for analysis. Phlebography and CDS examinations were inconclusive or were not completed for 19% of these patients (28/144). DVT was diagnosed by phlebography in 21% (24/116) of the remaining patients. Most of the thrombi were isolated calf DVTs (18/24). In contrast, DVT was diagnosed by CDS in 31% of these patients (36/116): only one case diagnosed by phlebography was missed by CDS. The specificity of CDS is thus 86% and its sensitivity is 96%. The positive predictive value is 64%, and the negative pred...Continue Reading

References

Jan 1, 1991·Journal of Clinical Epidemiology·D L SimelD B Matchar
May 1, 1990·Acta Radiologica·P KäleboB E Zachrisson
Jan 1, 1973·Acta Radiologica: Diagnosis·B E Zachrisson, H Jansen
Feb 1, 1972·Archives of Surgery·K Rabinov, S Paulin
Oct 1, 1994·Annals of Medicine·H J AronenS Bondestam
Apr 1, 1994·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·S C RoseF J Miller
Apr 18, 1998·JAMA : the Journal of the American Medical Association·S S AnandJ S Ginsberg
Dec 24, 2002·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Anders NorénStefan Rosfors

❮ Previous
Next ❯

Citations

Feb 25, 2009·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Katarina Nilsson-HelanderBengt I Eriksson
Dec 4, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Christopher John PannucciWendy L Wahl
Jul 31, 2008·Current Opinion in Pulmonary Medicine·Sebastian M Schellong
May 16, 2012·Annals of Surgery·Christopher J PannucciSachin Kheterpal
Sep 8, 2010·Thrombosis Journal·Stefan RosforsLasse J Lapidus
Dec 1, 2013·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·S Decker, M J Weaver
Oct 5, 2013·Chest·Christopher J PannucciPeter K Henke
Aug 28, 2010·Thrombosis Research·Marie-Thérèse BarrellierUNKNOWN GETHCAM study group
Jun 2, 2009·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L M PerssonS Rosfors
Mar 1, 2012·Injury·Muhammad J SultanCharles N McCollum
Jan 30, 2014·Blood·Gualtiero Palareti
Apr 30, 2016·Internal and Emergency Medicine·Angelo PorfidiaRaffaele Landolfi
Dec 3, 2016·The Bone & Joint Journal·E Domeij- ArverudP W Ackermann
Sep 1, 2018·The American Journal of Sports Medicine·Simon SvedmanPaul W Ackermann
Apr 19, 2007·The British Journal of Surgery·M T StenderO Thorlacius-Ussing
Apr 23, 2015·Journal of Orthopaedic Trauma·Rita SelbyUNKNOWN D-KAF (Dalteparin in Knee-to-Ankle Fracture) Investigators
Apr 22, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Simon SvedmanPaul W Ackermann
Apr 22, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·I A SaarensiltaP W Ackermann
Oct 25, 2007·The Journal of Bone and Joint Surgery. British Volume·S PatilA C W Hui
Nov 5, 2019·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Susanna AufwerberPaul W Ackermann
Oct 24, 2018·Plastic and Reconstructive Surgery. Global Open·Eric Swanson
Sep 30, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Li JiahaoWang Pengfei
Jul 15, 2021·BioMed Research International·Ze LinGuohui Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.