High Seropositivity Rate of Neutralizing Antibodies to Astrovirus VA1 in Human Populations.

Andrew B JanowskiDavid Wang


Astroviruses are common pathogens of the human gastrointestinal tract, but they have been recently identified from cases of fatal meningoencephalitis. Astrovirus VA1 is the most frequently detected astrovirus genotype from cases of human encephalitis, but the prevalence of neutralizing antibodies to VA1 in human sera is unknown. We developed a focus reduction neutralization assay (FRNT) for VA1 and measured the seroprevalence of neutralizing antibodies from two cohorts of adult and pediatric serum samples: (i) an age-stratified cohort from St. Louis, MO, collected from 2007 to 2008 and (ii) a cohort from the Peruvian Amazonian River Basin collected in the late 1990s. In the St. Louis cohort, the lowest seropositivity rate was in children 1 year of age (6.9%), rising to 63.3% by ages 9 to 12, and 76.3% of adults ≥20 years were positive. The Peruvian Amazon cohort showed similar seropositivity rates across all ages, with individuals under age 20 having a rate of 75%, while 78.2% of adults ≥20 years were seropositive. In addition, we also identified the presence neutralizing antibodies to VA1 from commercial lots of intravenous immunoglobulin (IVIG). Our results demonstrate that a majority of humans are exposed to VA1 by adulthood...Continue Reading


Jul 19, 1975·Lancet·C R Madeley, B P Cosgrove
Sep 6, 1975·Lancet·C R Madeley, B P Cosgrove
Nov 17, 1978·Medical Microbiology and Immunology·J Kurtz, T Lee
Feb 10, 1998·Clinical and Diagnostic Laboratory Immunology·M P KoopmansJ Vinjé
Mar 27, 1999·The Pediatric Infectious Disease Journal·D K MitchellM J Carter
Apr 10, 2008·PLoS Pathogens·Stacy R FinkbeinerDavid Wang
Aug 21, 2009·The Journal of General Virology·A KapoorE Delwart
Sep 16, 2009·Emerging Infectious Diseases·Nang L NguyenDavid Wang
Oct 10, 2009·Virology Journal·Stacy R FinkbeinerDavid Wang
Dec 25, 2009·Emerging Infectious Diseases·Nigel A CunliffeMartyn Regan
May 29, 2010·Emerging Infectious Diseases·Phenix Lan QuanW Ian Lipkin
Apr 30, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Tung Gia PhanEric Delwart
May 3, 2014·Clinical and Vaccine Immunology : CVI·Lori R HoltzDavid Wang
Aug 26, 2014·Emerging Infectious Diseases·Efrem S LimRobert L Garcea
Oct 4, 2014·Clinical Microbiology Reviews·Albert BoschSusana Guix
Jan 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Samia N NaccacheCharles Y Chiu
Jan 13, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Julianne R BrownJudith Breuer
May 16, 2015·Virology Journal·Caroline T MeyerLori R Holtz
Jul 24, 2015·The Lancet Global Health·James A Platts-MillsUNKNOWN MAL-ED Network Investigators
Sep 26, 2015·Journal of the Pediatric Infectious Diseases Society·M-L FrémondM Eloit
Mar 19, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Masanori SatoKeiko Tanaka-Taya
Apr 19, 2016·Emerging Infectious Diseases·Samuel CordeyLaurent Kaiser
Oct 28, 2016·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Su Han LumRobert Wynn
Jul 14, 2017·Journal of Virology·Andrew B JanowskiDavid Wang
May 28, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Zexin TaoAiqiang Xu
Jun 13, 2019·The New England Journal of Medicine·Michael R WilsonCharles Y Chiu
Jul 11, 2019·MBio·Andrew B JanowskiDavid Wang
Nov 24, 2019·Journal of Medical Case Reports·Georgia KoukouSonja Jacobsen
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immunoprecipitation assay

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