High serum D-lactate in patients on continuous ambulatory peritoneal dialysis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Y S AndersonP Altmann

Abstract

As abnormally high serum D-lactate levels may cause neurological impairment, we determined whether patients undergoing continuous ambulatory peritoneal dialysis (CAPD) with lactate-containing fluids have increased serum D-lactate concentrations. D- and L-lactate concentrations were determined in peritoneal dialysis fluids and in serum from control subjects (n = 10), haemodialysis patients (n = 10), and CAPD patients (n = 30) before and after 1 h of dialysis. We found the median D-lactate concentration in Dianeal CAPD fluid to be 26 mM (range 19-27), whereas it was less than 0.5 mM in DPCA2 fluid. Control, haemodialysis, and CAPD (DPCA2) patient median serum D-lactate concentrations were below 0.07 mM. However, CAPD (Dianeal) patient serum D-lactate concentrations were 4-fold higher than controls (P < 0.0001), at 0.28 mM, an hour after instillation of D-lactate-containing fluid. Three patients, whose serum D-lactate averaged 0.59 mM, were found to have D-lactate concentrations at 0.22 mM after overnight cessation of dialysis. We conclude that CAPD with D-lactate-containing fluids raises serum D-lactate to abnormal levels.

Citations

Oct 6, 2005·Journal of Pediatric Gastroenterology and Nutrition·Eamonn ConnollyBengt Björkstén
Apr 19, 2005·Shock·Kristan L StaudenmayerEileen M Bulger
Apr 28, 2009·Metabolism: Clinical and Experimental·Eszter KargSándor Túri
Aug 8, 2006·Annales Françaises D'anesthèsie Et De Rèanimation·O CollangeB Dureuil
Dec 9, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Davide G A M BianchettiGregorio P Milani
Jul 21, 2020·BioMed Research International·Miroslav Pohanka

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