PMID: 11325081Apr 28, 2001Paper

High serum level of procollagen type III amino-terminal peptide contributes to the efficacy of spironolactone and angiotensin-converting enzyme inhibitor therapy on left ventricular hypertrophy in essential hypertensive patients

Hypertension Research : Official Journal of the Japanese Society of Hypertension
A SatoTakao Saruta

Abstract

We recently demonstrated that spironolactone may have beneficial effects on left ventricular hypertrophy in selected patients with essential hypertension undergoing treatment with an angiotensin-converting enzyme (ACE) inhibitor. To clarify the possible mechanisms by which spironolactone improves cardiac hypertrophy, we investigated the change in serum procollagen type III amino-terminal peptide (PIIINP) in 11 patients with essential hypertension treated with spironolactone and an ACE inhibitor for 24 weeks. Both blood pressure and serum PIIINP levels were significantly decreased by treatment. There was a statistical significant correlation between the changes in LVMI and those in PIIINP. The reduction in PIIINP was significant in patients whose initial serum PIIINP levels were above the normal range. Before treatment, there were no statistically significant correlations between serum PIIINP levels and either LVMI, blood pressure, or plasma aldosterone concentration. Essential hypertensive patients matched in terms of duration of therapy, blood pressure and LVMI and treated with an ACE inhibitor alone showed no change in serum PIIINP levels. In conclusion, the results of the present study demonstrate that patients with essentia...Continue Reading

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Citations

Jun 24, 2004·Current Treatment Options in Cardiovascular Medicine·Anita Deswal, David Yao
Mar 17, 2007·Current Hypertension Reports·Hari Krishnan Parthasarathy, Thomas M MacDonald
Jan 18, 2003·Current Hypertension Reports·Mario Fritsch Neves, Ernesto L Schiffrin
May 1, 2009·Heart Failure Reviews·Faiez ZannadWafae Iraqi
Jan 2, 2016·Journal of Cardiac Failure·Ibrahim N MansourLarisa H Cavallari
Jul 28, 2009·Heart Failure Clinics·Faiez Zannad, Bertram Pitt
Feb 24, 2007·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Mesut DemirMurat Cayli
Jul 11, 2008·Journal of Clinical Pharmacy and Therapeutics·R MariottiL Rondinini
Nov 28, 2006·European Journal of Heart Failure·Colin BerryJohn McMurray
Jun 17, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Atsuhisa Sato, Takao Saruta
Jan 4, 2003·Hypertension·Atsuhisa SatoTakao Saruta
Dec 15, 2017·Circulation Research·Miranda E GoodKodi S Ravichandran
Jan 13, 2006·Current Opinion in Lipidology·Johan Sundström, Ramachandran S Vasan

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