High serum levels of 8-OHdG are an independent predictor of post-stroke depression in Chinese stroke survivors

Neuropsychiatric Disease and Treatment
Zhihua LiuJincai He

Abstract

Although previous studies have investigated oxidative stress biomarkers in association with depression in non-stroke subjects, the association between oxidative deoxyribonucleic acid damage and post-stroke depression (PSD) remains unelucidated. Two hundred forty-one first-ever ischemic stroke patients were consecutively recruited within the first 24 h of stroke onset and were followed up at 1 month. Serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) and catalase (CAT) levels were measured within 24 h of admission using a commercially available enzyme-linked immunosorbent assay. The 17-item Hamilton Depression Scale was used to evaluate depressive symptoms. Diagnosis of PSD was made in line with theDiagnostic and Statistical Manual of Mental Disorders, 4th edition criteria for depression. Serum levels of 8-OHdG (P<0.001) and CAT (P=0.025) increased in depressed patients at admission. A positive correlation was found between the 8-OHdG and CAT levels in both the total stroke patients (r=0.320,P<0.001) and the depressed patients (r=0.300,P=0.012). The 8-OHdG levels were positively correlated with the 17-item Hamilton Depression Scale scores (r=0.129,P=0.046) in depressed patients. Multivariate analyses found that 8-OHdG levels ≥200.0 ng/L...Continue Reading

Citations

Dec 29, 2020·Brain Research Bulletin·Ankan SarkarPallab Bhattacharya

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
MedCalc

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.