High serum levels of proinflammatory markers during epileptogenesis. Can omega-3 fatty acid administration reduce this process?

Epilepsy & Behavior : E&B
T L F GouveiaM G Naffah-Mazzacoratti

Abstract

During the epileptogenic process, several events may occur, such as an important activation of the immune system in the central nervous system. The response to seizure activity results in an inflammation in the brain as well as in the periphery. Moreover, CRP and cytokines may be able to interact with numerous ligands in response to cardiac injury caused by sympathetic stimulation in ictal and postictal states. Based on this, we measured the serum levels of C-reactive protein (CRP) and cytokines during acute, silent, and chronic phases of rats submitted to the pilocarpine model of epilepsy. We have also analyzed the effect of a chronic treatment of these rats with omega-3 fatty acid in CRP and cytokine levels, during an epileptic focus generation. C-reactive protein and cytokines such as IL-1β, IL-6, and TNF-α presented high concentration in the blood of rats, even well after the occurrence of SE. We found reduced levels of CRP and all proinflammatory cytokines in the blood of animals with chronic seizures, treated with omega-3, when compared with those treated with vehicle solution. Taken together, our results strongly suggest that the omega-3 is an effective treatment to prevent SUDEP occurrence due to its capability to act a...Continue Reading

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Citations

Dec 31, 2016·Epilepsia·Teresa RavizzaAlon Friedman
Jun 13, 2019·Nutrients·Ji-Eun Kim, Kyung-Ok Cho
Feb 28, 2020·Experimental and Therapeutic Medicine·Jinjie LiuSibo Liu
Jun 28, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Antonio LeoEmilio Russo
Mar 7, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jaysingh SinghJeffrey Britton

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