High Serum Serotonin Predicts Increased Risk for Hip Fracture and Nonvertebral Osteoporotic Fractures: The MrOS Sweden Study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Hallgerdur Lind KristjansdottirDan Mellström

Abstract

Because several studies have implicated serotonin as a regulator of bone mass, we here explore its potential association on fracture risk and falls, as on bone mineral density (BMD) and muscle strength, in humans. Serum levels of serotonin were analyzed in 950 men (aged 69 to 81 years), participating in the Gothenburg part of the population-based study MrOS Sweden. Men taking selective serotonin reuptake inhibitors (SSRIs) had a mean value of 31.2 μg/L compared with 159.4 μg/L in those not taking SSRIs. SSRI users were excluded from further analysis. During 10-year follow-up, 224 men exhibited fractures, including 97 nonvertebral osteoporotic fractures (57 hip fractures), and 86 vertebral fractures. Serotonin was associated with hip fracture in linear analysis (hazard ratio [HR] = 1.27, 95% confidence interval [CI] 1.03-1.58) and to all fractures in a nonlinear manner, when quintiles of serotonin was included in quadratic terms (HR = 1.12, 95% CI 1.04-1.21). Men in serotonin quintile 5 had, in multivariable analysis, a HR of 2.30 (95% CI 1.31-4.02) for hip fracture and 1.82 (95% CI 1.17-2.85) for nonvertebral fractures compared with men in quintiles 1 to 4. Men in quintile 1 had, in multivariable analysis, a HR of 1.76 (95% CI ...Continue Reading

References

Sep 24, 1998·The New England Journal of Medicine·P B ThapaW A Ray
Jun 2, 2001·The Journal of Biological Chemistry·I WestbroekP J Nijweide
Nov 24, 2001·Cell·Y GongUNKNOWN Osteoporosis-Pseudoglioma Syndrome Collaborative Group
May 17, 2002·The New England Journal of Medicine·Lynn M BoydenRichard P Lifton
Oct 9, 2002·Journal of the American Geriatrics Society·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Feb 1, 2006·Experimental Gerontology·David K ChowCatherine A Wolkow
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dan MellströmClaes Ohlsson
Jan 24, 2007·Archives of Internal Medicine·J Brent RichardsUNKNOWN Canadian Multicentre Osteoporosis Study Research Group
Sep 12, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C ColletM-C de Vernejoul
Dec 10, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jenny M KindblomDan Mellström
Feb 13, 2009·Journal of Pharmacological Sciences·Takao HiraiHiroaki Nishio
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ulrike I MödderSundeep Khosla
Nov 16, 2010·Annual Review of Medicine·Gerard Karsenty, Vijay K Yadav
Jan 5, 2011·Journal of Affective Disorders·Bianca A van MilligenBrenda W J H Penninx
May 24, 2011·Nature Medicine·Yajun CuiAlexander G Robling
Sep 10, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Q WuM D Crowell
Jan 20, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chun-Sick EomKyung-Hwan Cho
Feb 8, 2013·Nature Medicine·Roland Baron, Michaela Kneissel
May 2, 2013·The Journal of Clinical Endocrinology and Metabolism·Jennifer S WalshRichard Eastell
Apr 8, 2015·Journal of Internal Medicine·U H Lerner, C Ohlsson
Jun 1, 2015·European Journal of Pharmacology·Kenjiro TanakaAkifumi Togari
Apr 1, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ruin MoaddelLuigi Ferrucci
Sep 12, 2016·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Mee Kyoung KimKi-Hyun Baek
Nov 9, 2016·Scandinavian Journal of Clinical and Laboratory Investigation·Qiu-Shi WeiWei-Min Deng

❮ Previous
Next ❯

Citations

Dec 14, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C H ValaD Mellström
Aug 4, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Peter Vestergaard
Dec 15, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H L KristjansdottirC Lewerin

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Claes OhlssonLiesbeth Vandenput
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Sophie A JamalDouglas C Bauer
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Hans JutbergerDan Mellström
Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
C MouraE Rahme
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
H JohanssonDan Mellström
© 2022 Meta ULC. All rights reserved