High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: the JPHC study

Atherosclerosis
Renzhe CuiJPHC Study Group

Abstract

High serum total cholesterol levels represent a risk factor of ischemic stroke in Western countries. However, this association has not been thoroughly investigated in Asian populations where the incidence of stroke is high. Participants were 11,727 men and 21,742 women aged 40-69 years, all free of cardiovascular disease and cancer at baseline. During the median 12-year follow-up, we documented 612 ischemic stroke (293 lacunar infarction, 107 large-artery occlusive infarctions, and 168 embolic infarctions). Excess risk of ischemic stroke was observed in men with serum total cholesterol levels of ≥ 6.21 mmol/L than those with the lowest category (<4.65 mmol/L), but not in women. The multivariable hazard ratios (HRs) and 95% confidence interval (95% CI) were 1.63 (1.14-2.35) for men and 1.03 (0.69-1.55) for women. The corresponding HRs of large-artery occlusive infarction were 2.86 (1.31-6.27) for men and 0.75 (0.28-2.01) for women. Serum total cholesterol levels were not associated with risk of lacunar or embolic infarction for either sex. High serum total cholesterol is a risk factor of ischemic stroke, specifically large-artery occlusive infarction for Japanese men.

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Citations

Oct 5, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Masaki Ohsawa, Kozo Tanno
Nov 7, 2013·PloS One·Shaoyong XuUNKNOWN China National Diabetes and Metabolic Disorders Study Group
Mar 4, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Binod K YadavByoung-Soo Shin
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Sep 5, 2014·Journal of Atherosclerosis and Thrombosis·Daisuke SugiyamaHirotsugu Ueshima
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Jul 7, 2017·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Nader ParsaMaurizio Trevisan
Oct 10, 2015·Stroke; a Journal of Cerebral Circulation·Shadi Yaghi, Mitchell S V Elkind
Jan 4, 2019·Stroke; a Journal of Cerebral Circulation·Daniel G Hackam, Robert A Hegele
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Oct 2, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Francesco ArbaDomenico Inzitari

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