High Serum Uric Acid Levels Could Be a Risk Factor of Hepatocellular Carcinoma Recurrences.

Nutrition and Cancer
Masamichi HayashiYasuhiro Kodera

Abstract

The Apolipoprotein-related MORtality RISk (AMORIS) study in Sweden revealed that serum uric acid (SUA) was significantly associated with hepatobiliary cancer occurrence. However, the association with postoperative hepatocellular carcinoma (HCC) recurrence has not been reported. A total of 256 surgically resected HCC patients were included (from January 2003 to December 2017) in this study. Comparisons in terms of clinicopathologic factors and long-term outcomes were made between patients with high SUA (>6.1 mg/dl) at the time of hepatectomy and low SUA. Besides, SUA data at one postoperative year (1POY) of the same cohort were collected and analyzed in the same manner. About 88.8% of tumor relapse sites were the remnant liver. High SUA levels were associated with male and well-differentiated HCCs. Recurrence-free survival (RFS) of high SUA patients was significantly inferior to low SUA patients [median survival time (MST): 22.7 vs. 28.5 mo, P = 0.033], whereas no difference was observed in overall survival (MST: both not reached, P = 0.771). RFS of high SUA patients at 1POY also showed significantly poorer outcomes than low SUA patients (MST: 29.3 vs. 57.0 mo, P = 0.049). High SUA implies a significant risk factor of activating...Continue Reading

References

Feb 2, 2013·Clinical and Translational Medicine·Mehdi A FiniRichard M Wright
Mar 13, 2014·Pathology Oncology Research : POR·Eun ShinNam Hee Won
Jan 30, 2015·World Journal of Gastroenterology : WJG·Christopher LeungPeter W Angus
Jun 18, 2016·Cancer Biomarkers : Section a of Disease Markers·You-Fang ChenWei-An Zeng
Jun 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yong LiShu-Fan Yin
Oct 13, 2016·World Journal of Gastroenterology : WJG·Carrie R WongJoseph K Lim
Oct 8, 2019·Public Health Nutrition·Michelle Timóteo da SilvaSandhi Maria Barreto
Nov 18, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Samantha M RuffJonathan M Hernandez

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Citations

Jul 3, 2021·International Journal of Molecular Sciences·Pablo MurielErika Ramos-Tovar

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