High serum YKL-40 concentration is associated with severe bone disease in newly diagnosed multiple myeloma patients

European Journal of Haematology
Anne K MylinLene M Knudsen

Abstract

In multiple myeloma (MM) YKL-40 is present in the bone marrow microenvironment and is suggested to play a role in remodelling of the extracellular matrix. Here, the association between serum YKL-40 and severity of bone disease in MM is investigated. Serum YKL-40 was measured in 34 MM patients at diagnosis. Bone disease was assessed by radiography and biochemical markers of bone metabolism. Patients were treated with conventional chemotherapy and followed for up to 30 months. Patients with a serum YKL-40 elevated above the age specific reference range (56%) had a higher total X-ray score (P = 0.003) and higher levels of the markers of bone resorption serum C-terminal telopeptide of collagen type I (P = 0.003), urine pyridinoline (P = 0.04) and urine deoxypyridinoline (P = 0.002), while the levels of urine N-terminal telopeptide of collagen type I (NTX-1) and the markers of bone formation equalled those seen in patients with a normal serum YKL-40. Serum YKL-40 level (beta = 7.6; P = 0.002) and urine NTX-1 (log(2)) (beta = 3.5; P = 0.006) were independent predictors of total X-ray score at diagnosis. Patients with elevated serum YKL-40 at diagnosis had shorter time to first osteolytic event compared to patients with normal serum Y...Continue Reading

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Citations

Jan 13, 2009·BMC Cancer·Estrid V S HøgdallLise H Christensen
Oct 2, 2009·Future Oncology·Julia S JohansenBenny V Jensen
Jan 13, 2015·Leukemia & Lymphoma·Anne K MylinUNKNOWN Nordic Myeloma Study Group
Nov 4, 2015·Frontiers in Pharmacology·Daniele TibulloFrancesco Di Raimondo
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Anne K MylinLene M Knudsen
Apr 3, 2014·European Journal of Haematology·Mads Emil BjørnHans C Hasselbalch
Oct 29, 2015·BioMed Research International·Alan KirwanMichelle Kilcoyne
Jan 21, 2014·Bone·Michelino Di RosaLucia Malaguarnera
Jul 22, 2016·Current Allergy and Asthma Reports·Daniel Elieh Ali KomiAnton Pieter Bussink

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