High shear mixing granulation of ibuprofen and beta-cyclodextrin: effects of process variables on ibuprofen dissolution

AAPS PharmSciTech
Mohamed K Ghorab, M C Adeyeye

Abstract

The aims of the study were to evaluate the effect of high shear mixer (HSM) granulation process parameters and scale-up on wet mass consistency and granulation characteristics. A mixer torque rheometer (MTR) was employed to evaluate the granulating solvents used (water, isopropanol, and 1:1 vol/vol mixture of both) based on the wet mass consistency. Gral 25 and mini-HSM were used for the granulation. The MTR study showed that the water significantly enhanced the beta-cyclodextrin (beta CD) binding tendency and the strength of liquid bridges formed between the particles, whereas the isopropanol/water mixture yielded more suitable agglomerates. Mini-HSM granulation with the isopropanol/water mixture (1:1 vol/vol) showed a reduction in the extent of torque value rise by increasing the impeller speed as a result of more breakdown of agglomerates than coalescence. In contrast, increasing the impeller speed of the Gral 25 resulted in higher torque readings, larger granule size, and consequently, slower dissolution. This was due to a remarkable rise in temperature during Gral granulation that reduced the isopropanol/water ratio in the granulating solvent as a result of evaporation and consequently increased the beta CD binding strengt...Continue Reading

References

Nov 1, 1985·Chemical & Pharmaceutical Bulletin·Y NakaiA Kajiyama
Feb 1, 1984·Chemical & Pharmaceutical Bulletin·E FenyvesiT Nagai
Aug 1, 1996·The Journal of Pharmacy and Pharmacology·A Muñoz-Ruiz, P Paronen
Sep 22, 1998·Pharmaceutical Development and Technology·A FaureM J Cliff
Apr 22, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A FaureM J Cliff
Sep 16, 1999·International Journal of Pharmaceutics·H EliasenT Schaefer
Mar 21, 2000·International Journal of Pharmaceutics·S I BadawyD L Gilbert
Jun 22, 2001·Pharmaceutical Development and Technology·P HolmC Larsen
Aug 4, 2001·Pharmaceutical Development and Technology·M K Ghorab, M C Adeyeye
Nov 28, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Dieter AmeyeDesire L Massart
Jul 29, 2003·Journal of Pharmaceutical Sciences·Mohamed K Ghorab, Moji Christianah Adeyeye
Dec 15, 2004·Drug Development and Industrial Pharmacy·Alessandro GainottiFerdinando Giordano
Mar 12, 2005·AAPS PharmSciTech·Sherif I Farag Badawy, Munir A Hussain
Apr 2, 2005·Chemical & Pharmaceutical Bulletin·Satoru WatanoYoshifumi Osako
Dec 6, 2005·Chemical & Pharmaceutical Bulletin·Yoshinobu SatoSatoru Watano

❮ Previous
Next ❯

Citations

Jun 21, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Bhatu P Badgujar, Atish S Mundada
Dec 23, 2011·Drug Development and Industrial Pharmacy·Rutesh H DaveLabdhi D Contractor
Jan 1, 2012·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Walid F SakrAdel A Sakr
May 5, 2020·Drug Development and Industrial Pharmacy·Amr KhaledOmaima A Sammour

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.