High shear stress influences plaque vulnerability Part of the data presented in this paper were published in Stroke 2007;38:2379-81.

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
Harald C GroenJ J Wentzel

Abstract

Shear stress of the blood at the vessel wall plays an important role in many processes in the cardiovascular system primarily focused on the regulation of vessel lumen and wall dimensions. There is ample evidence that atherosclerotic plaques are generated at low shear stress regions in the cardiovascular system, while high shear stress regions are protected. In the course of plaque progression, advanced plaques start to encroach into the lumen, and thereby start to experience high shear stress at the endothelium. Until now the consequences of high shear stress working at the endothelium of an advanced plaque are unknown. As high shear stress influences tissue regression, we hypothesised that high shear stress can destabilise the plaque by cap weakening leading to ulceration. We investigated this hypothesis in a magnetic resonance imaging (MRI) dataset of a 67-year-old woman with a plaque in the carotid artery at baseline and an ulcer at ten-month follow-up. The lumen, plaque components (lipid/necrotic core, intraplaque haemorrhage) and ulcer were reconstructed three dimensionally and the geometry at baseline was used for shear stress calculation using computational fluid dynamics. Correlation of the change in plaque composition...Continue Reading

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Citations

Dec 19, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Renu VirmaniFrank D Kolodgie
Jul 14, 2010·The International Journal of Cardiovascular Imaging·E E van der WallJ D Schuijf
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Aug 20, 2011·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Dae Chul SuhJong Sung Kim
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Aug 29, 2014·DNA and Cell Biology·Xiaohong LiDangheng Wei
May 8, 2018·Medical & Biological Engineering & Computing·Pengsrorn Chhai, Kyehan Rhee
Dec 20, 2019·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Guillaume GoudotMathieu Pernot

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