High Signal Intensity on T2-Weighted Cardiovascular Magnetic Resonance Imaging Predicts Life-Threatening Arrhythmic Events in Hypertrophic Cardiomyopathy Patients

Circulation Journal : Official Journal of the Japanese Circulation Society
Yasuki HenTsutomu Yoshikawa

Abstract

The prognostic value of high signal intensity on T2-weighted cardiovascular magnetic resonance imaging (T2 high signal) in hypertrophic cardiomyopathy (HCM) patients in a single-center cohort was investigated.Methods and Results:A total of 237 HCM patients (median age, 62 years; 143 male) underwent T2-weighted, cine and late gadolinium enhancement (LGE) imaging, and were followed (median duration, 3.4 years) for life-threatening arrhythmic events. The clinical and magnetic resonance imaging characteristics were extracted, and predictors of life-threatening arrhythmic events were assessed on multivariate analysis. LGE was present in 180 patients (75.9%). Median LGE score was 3 in a left ventricle 17-segment model. T2 high signal was present in 49 patients (20.7%). The annual events rate was significantly higher in patients with extensive LGE (score ≥4) than in those without (3.0%/year vs. 0.5%/year, P=0.011). On multivariate analysis, extensive LGE (hazard ratio, 5.650; 95% CI: 1.263-25.000, P=0.024) as an independent predictor for life-threatening arrhythmic events. In patients with extensive LGE, the annual events rate was significantly higher in patients with T2 high signal than in those without (5.8%/year vs. 0.9%/year, P=0....Continue Reading

References

Dec 29, 2000·Journal of the American College of Cardiology·P M ElliottW J McKenna
Jun 15, 2004·Journal of the American College of Cardiology·James C C MoonDudley J Pennell
Jul 24, 2007·International Journal of Cardiology·Paola MelaciniSabino Iliceto
Jul 27, 2007·JAMA : the Journal of the American Medical Association·Barry J MaronPaolo Bruzzi
Feb 2, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Imke ChristiaansArthur A M Wilde
Oct 15, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Ichiro TakeuchiTohru Izumi
Oct 16, 2013·European Heart Journal·Constantinos O'MahonyUNKNOWN Hypertrophic Cardiomyopathy Outcomes Investigators
Feb 14, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki HenTetsuya Sumiyoshi
Jul 7, 2014·Journal of the American College of Cardiology·Barry J MaronMartin S Maron
Feb 5, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·UNKNOWN JCS Joint Working Group
Feb 24, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Yasuki HenTsutomu Yoshikawa
Jul 28, 2016·JACC. Cardiovascular Imaging·Zhen WengYang He
Oct 13, 2016·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Rui PlácidoCarlos E Rochitte
Oct 21, 2016·Journal of Computer Assisted Tomography·Yasuo AmanoShinichiro Kumita
Mar 28, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Ken KatoYoshio Kobayashi
Oct 25, 2017·The International Journal of Cardiovascular Imaging·D H Frank GommansMarcel J M Kofflard

❮ Previous
Next ❯

Citations

Jan 28, 2020·Annual Review of Medicine·Yuchi HanVictor A Ferrari
Jun 21, 2020·Current Cardiology Reports·Chrysanthos GrigoratosGiovanni Donato Aquaro
Sep 19, 2020·La Radiologia medica·Silvia PradellaVittorio Miele
Apr 23, 2021·Future Cardiology·Nishant LahotiBrian Xiangzhi Wang
Oct 26, 2021·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Elizabeth W ThompsonYuchi Han
Nov 2, 2021·European Journal of Sport Science·Constantinos BakogiannisEmmanuel Androulakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.