High sodium intake and sodium to potassium ratio may be linked to subsequent increase in vascular damage in adults aged 40 years and older: the Korean multi-rural communities cohort (MRCohort)

European Journal of Nutrition
Sukyoung JungMin-Ho Shin

Abstract

Subclinical vascular damage is a chronic intermediate process in cardiovascular disease (CVD) and high sodium (Na) has been regarded as an adverse factor in subclinical vascular health; however, the longitudinal relationship between Na intake and subclinical vascular damage has not been studied. We aimed to evaluate the longitudinal relationship of dietary Na intake and sodium to potassium ratio (Na:K) with brachial-ankle pulse wave velocity (baPWV) and carotid intima media thickness (cIMT) in healthy adults aged 40 years and older in Korea. The present study was based on participants (n = 2145 for baPWV analysis and n = 2494 for cIMT analysis) who visited three times during 2005-2013 (median 5.3 years of follow-up). We used both dietary Na intake and Na:K at baseline and its average (baseline, 2nd, 3rd), which was obtained from food frequency questionnaire (FFQ) as exposure at every visit. baPWV and cIMT levels at the third visit and change from baseline to the third visit were used to represent the level of subclinical vascular damage. After adjustment for potential confounders, significant positive relationships between dietary Na intake and both baPWV3rd and cIMT3rd were observed (baPWV: p for trend ≤ 0.0001 for Naaverage; ...Continue Reading

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Citations

Dec 22, 2019·Nutrients·Christiana TsirimiagkouKalliopi Karatzi
Feb 12, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sukyoung JungYoung-Hoon Lee
May 1, 2021·Nutrients·Diriba B KumssaMartin R Broadley
Jul 26, 2021·Journal of the Academy of Nutrition and Dietetics·Anna VaudinNadine R Sahyoun
Dec 23, 2021·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Akshaya Srikanth BhagavathulaJamal Rahmani

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