High Soluble CD14 Levels at Primary HIV-1 Infection Predict More Rapid Disease Progression

The Journal of Infectious Diseases
Evguenia KrastinovaANRS PRIMO Cohort

Abstract

The soluble CD14 (sCD14) level was found associated with mortality during the chronic phase of human immunodeficiency virus (HIV) infection. Here we assessed its prognostic value in 138 patients with primary HIV infection. Higher sCD14 levels were associated with death, from myocardial infarction, but this was based on 3 deaths only. Among 68 untreated patients, those with higher sCD14 levels had more rapid spontaneous CD4 cell decline during the first 18 months following primary infection. This association persisted after adjustment for age, the CD4 cell count, and HIV viral load at diagnosis.

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Citations

Aug 18, 2016·The American Journal of Drug and Alcohol Abuse·Mollie A Monnig
Dec 7, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sophie NovelliCécile Goujard
Jul 20, 2017·The American Journal of Tropical Medicine and Hygiene·Nona M JiangWilliam A Petri
May 26, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·John R KoetheSpyros A Kalams
Jul 2, 2019·AIDS·Fernanda de Oliveira Feitosa de CastroSimone Gonçalves da Fonseca
Aug 24, 2017·BMC Infectious Diseases·Francesca FalascaOmbretta Turriziani
Jun 20, 2018·Frontiers in Immunology·Sixtine CoindreUNKNOWN ANRS CO6 PRIMO Cohort
Dec 11, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ronald J EllisRobert K Heaton
Jun 14, 2021·The Journal of Antimicrobial Chemotherapy·Ana González-CordónUNKNOWN NEAT022 Study Group

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