Abstract
We present three-dimensional (3-D) high-resolution spectral-domain optical coherence microscopy (SD-OCM) by using a supercontinuum (SC) fiber laser source with 300-nm spectral bandwidth (full-width at half-maximum) in the 1700-nm spectral band. By using low-coherence interferometry with SC light and a confocal detection scheme, we realized lateral and axial resolutions of 3.4 and 3.8 μm in tissue (n = 1.38), respectively. This is, to the best of our knowledge, the highest 3-D spatial resolution reported among those of Fourier-domain optical coherence imaging techniques in the 1700-nm spectral band. In our SD-OCM, to enhance the imaging depth, a full-range method was implemented, which suppressed the formation of a coherent ghost image and allowed us to set the zero-delay position inside the samples. We demonstrated the 3-D high-resolution imaging capability of 1700-nm SD-OCM through the measurement of an interference signal from a mirror surface and imaging of a single 200-nm polystyrene bead and a pig thyroid gland. Deep tissue imaging at a depth of up to 1.8 mm was also demonstrated. This is the first demonstration of 3-D high-resolution SD-OCM in the 1700-nm spectral band.
References
Nov 1, 2003·Optics Letters·A D AguirreJ G Fujimoto
Sep 28, 2005·Gastrointestinal Endoscopy·Pei-Lin HsiungJames G Fujimoto
Dec 13, 2007·Optics Letters·E BeaurepaireJ Mertz
Nov 26, 2008·Optics Express·Utkarsh SharmaSeok H Yun
Dec 3, 2001·Optics Express·A FercherT Lasser
Apr 21, 2003·Optics Express·R LeitgebAdolf Fercher
May 31, 2004·Optics Express·Maciej WojtkowskiJay Duker
Apr 15, 1994·Optics Letters·J A IzattJ G Fujimoto
Mar 10, 2010·Journal of Biomedical Optics·Aaron D AguirreJames G Fujimoto
Jan 25, 2011·Biomedical Optics Express·V M KodachT G van Leeuwen
Feb 9, 2012·Biomedical Optics Express·Shutaro Ishida, Norihiko Nishizawa
Feb 15, 2012·Optics Express·Vivek J SrinivasanAlex E Cable
Nov 29, 2012·Optics Express·WooJhon ChoiJames G Fujimoto
Aug 14, 2013·Optics Express·Osman O AhsenJames G Fujimoto
Sep 7, 2013·Biomedical Optics Express·Hsiang-Chieh LeeJames G Fujimoto
Apr 2, 2014·Biomedical Optics Express·H KawagoeN Nishizawa
Apr 4, 2015·Optics Express·Masato TanakaTakemi Hasegawa
Oct 9, 2015·Journal of Biomedical Optics·Woo June Choi, Ruikang K Wang
Oct 30, 2015·Optics Letters·Shau Poh ChongVivek J Srinivasan
Aug 23, 2016·Scientific Reports·Masahito YamanakaNorihiko Nishizawa
Aug 5, 2017·Journal of Biomedical Optics·Hiroyuki KawagoeNorihiko Nishizawa
Nov 1, 2017·Optics Letters·Richard HaindlMengyang Liu
Aug 4, 2018·Scientific Reports·Kwan Seob ParkTae Joong Eom