High spatiotemporal resolution imaging of the neurovascular response to electrical stimulation of rat peripheral trigeminal nerve as revealed by in vivo temporal laser speckle contrast

Journal of Neuroscience Methods
Nan LiNitish V Thakor

Abstract

Previous studies have implicated the abnormal activation of the trigeminal system to be a factor in the pathogenesis of migraine. The relationship between vascular changes and migraine, however, is under considerable debate. In this study, temporal laser speckle contrast imaging is combined with ridge tracking based vessel detection to obtain high resolution (6.7 microm x 6.7 microm), high contrast images of cerebral vascular structure. For the first time, the vasomotor and blood flow responses to electrical stimulation in rat peripheral trigeminal system were obtained simultaneously. The system is capable of picking up individual vessels with diameters down to 30 microm. The spatial spread of the blood velocity response relative to the point of stimulation was studied. Analysis of branching vessels showed a 50+/-5% vs. 30+/-5% change in mean peak magnitude and a 54% per second vs. 17% per second change in mean rate of increase for vessels proximal vs. distal to the stimulation site. The penetration depth of the laser used was proven to be sufficient to image dural as well as cortical vessels through a thinned skull preparation. Different responses were observed from cortical and dural vessels. While the diameter of cortical ve...Continue Reading

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Citations

May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nan LiGalit Pelled
May 2, 2013·Biomedical Engineering Online·Lun-De LiaoNitish V Thakor
Apr 9, 2010·Biomedical Instrumentation & Technology·W Jason Naramore, Nee-Yin Chou
Jun 7, 2011·Journal of Biomedical Optics·Abhishek RegeNitish V Thakor
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lun-De LiaoYou-Yin Chen
Mar 13, 2014·British Journal of Pharmacology·S E Erdener, T Dalkara
Sep 19, 2009·Archives of Oral Biology·Takeharu NiiokaHiroshi Izumi
Feb 2, 2013·IEEE Reviews in Biomedical Engineering·Janaka SenarathnaNitish V Thakor
Jul 16, 2013·IEEE Transactions on Biomedical Circuits and Systems·Janaka SenarathnaNitish V Thakor
Nov 9, 2012·IEEE Transactions on Biomedical Circuits and Systems·Kartikeya MurariGert Cauwenberghs
Mar 2, 2016·IEEE Reviews in Biomedical Engineering·Pedro G VazJoao Cardoso
Dec 31, 2016·International Journal of Molecular Sciences·Salazar JonesXiaofeng Jia
Jan 11, 2013·Biomedical Optics Express·Lipei Song, Daniel S Elson
Nov 15, 2011·Biomedical Optics Express·Xuan LiuJin U Kang
Mar 14, 2019·Contrast Media & Molecular Imaging·Richa Gandhi, Charalampos Tsoumpas
Jun 27, 2019·Lasers in Surgery and Medicine·Nami DavoodzadehGuillermo Aguilar
Jul 23, 2020·Frontiers in Bioengineering and Biotechnology·David L HalaneyGuillermo Aguilar
Oct 16, 2018·Biomedical Optics Express·Nami DavoodzadehGuillermo Aguilar

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