High-speed optical coherence tomography of corneal opacities

Ophthalmology
Rahul N KhuranaDavid Huang

Abstract

To evaluate corneal opacities with optical coherence tomography (OCT). Prospective observational case series. Twenty-three eyes of 19 patients with corneal opacities referred to a tertiary medical center. Twenty-three consecutive eyes with corneal opacities were imaged with a high-speed corneal OCT prototype (Carl Zeiss Meditec, Inc., Dublin, CA). The OCT system operates at a speed of 2000 axial scans per second and a wavelength of 1.3 microm. Slit-scanning tomography (Orbscan II, software version 3.12; Bausch & Lomb, Inc., Rochester, NY) and ultrasound pachymetry (Corneo-Gage Plus; Sonogage, Cleveland, OH) also were performed. Central cornea thickness was measured by the 3 instruments. In eyes with central opacities (n = 17), OCT central cornea thickness measurements were statistically equivalent to ultrasound pachymetry, whereas Orbscan II measurements were significantly less than ultrasound pachymetry (difference, -132.7+/-143 microm; P = 0.006). The OCT and ultrasound pachymetry results were obtained for all eyes, whereas Orbscan was unable to provide readings in 4 eyes. In eyes with off-center opacities (n = 6), OCT and Orbscan II central cornea thickness measurements were statistically equivalent to ultrasound pachymetry....Continue Reading

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Related Concepts

Corneal Opacity
Tomography, Ultrasonic
Tomography, Optical Coherence

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