PMID: 8609460Feb 1, 1996Paper

High split-dose recovery in hypersensitive human fibroblasts: a case of induced radioresistance?

International Journal of Radiation Biology
M G AlsbeihE P Malaise

Abstract

We studied the extent of split-dose recovery in seven non-transformed human fibroblast cell lines of different intrinsic radiosensitivity (HF19, 1BR3, 149BR, 84BR, GM739, 180BR and AT2EM). Experiments were performed on both growing and plateau-phase cells. The seven cell lines displayed a wide range of intrinsic radiosensitivity. The D of plateau phase cells ranged from 0.56 (AT2EM) to 3.02 Gy (HF19). The recovery ratios (RR) of the three non-ataxic hypersensitive cell lines (84BR, GM739, and 180BR) were significantly higher than those predicted from the single-dose survival curves of both growing and plateau-phase cells. In addition, in these three hypersensitive cell lines the challenge dose survival curve generated after different priming doses showed a reduction in the intrinsic radiosensitivity; the high RRs observed were due both to beta and a reduction in alpha. This suggests that a protective mechanism may be triggered by the first irradiation leading to induced radioresistance. For growing cells, the relationship between ln RR and 2D2 was well fitted by linear regression. With plateau phase cells, RR appeared to be dose dependent in a more complex fashion. Thus, no single value of beta RR was representative of the spli...Continue Reading

References

Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·X YangG G Steel
Feb 1, 1992·Mutation Research·J D Shadley, G Q Dai
Sep 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·X YangG G Steel
Nov 1, 1990·British Journal of Cancer·A HolmesG G Steel
Nov 1, 1989·International Journal of Radiation Biology·G G SteelJ H Peacock
Nov 1, 1989·International Journal of Radiation Biology·E P MalaiseB Fertil
Dec 1, 1989·International Journal of Radiation Biology·C B Seymour, C Mothersill
Dec 1, 1988·International Journal of Radiation Biology·J H PeacockG G Steel
Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·B Fertil, E P Malaise
Apr 1, 1994·International Journal of Radiation Biology·B SinghM C Joiner
Oct 24, 1959·Nature·M M ELKIND, H SUTTON

❮ Previous
Next ❯

Citations

May 20, 1998·Head & Neck·K Pekkola-HeinoR Grenman
Dec 12, 2019·Nucleic Acids Research·Iris EkeC Norman Coleman
Jan 20, 2012·Molecular and Cellular Biochemistry·Divyalakshmi SainiM Seshadri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.