High Streptococcus pneumoniae colonization prevalence among HIV-infected Kenyan parents in the year before pneumococcal conjugate vaccine introduction

BMC Infectious Diseases
Laura M ConklinDaniel R Feikin

Abstract

Streptococcus pneumoniae is a leading cause of pneumonia, meningitis and sepsis in developing countries, particularly among children and HIV-infected persons. Pneumococcal oropharyngeal (OP) or nasopharyngeal (NP) colonization is a precursor to development of invasive disease. New conjugate vaccines hold promise for reducing colonization and disease. Prior to introduction of 10-valent pneumococcal conjugate vaccine (PCV10), we conducted a cross-sectional survey among HIV-infected parents of children <5 years old in rural Kenya. Other parents living with an HIV-infected adult were also enrolled. After broth enrichment, NP and OP swabs were cultured for pneumococcus. Serotypes were identified by Quellung. Antimicrobial susceptibility was performed using broth microdilution. We enrolled 973 parents; 549 (56.4%) were HIV-infected, 153 (15.7%) were HIV-uninfected and 271 (27.9%) had unknown HIV status. Among HIV-infected parents, the median age was 32 years (range 15-74) and 374/549 (68%) were mothers. Pneumococci were isolated from 237/549 (43.2%) HIV-infected parents and 41/153 (26.8%) HIV-non-infected parents (p = 0.0003). Colonization with PCV10 serotypes was not significantly more frequent in HIV-infected (12.9%) than HIV-uninf...Continue Reading

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Citations

Mar 2, 2017·Indian Journal of Pediatrics·Qian WangHaibin Zhao
Feb 10, 2017·BMC Infectious Diseases·Eric S DonkorHans-Christian Slotved
Dec 21, 2018·Scientific Reports·Fernanda C LessaCynthia G Whitney
Oct 1, 2020·Open Forum Infectious Diseases·Jennifer L FarrarFabiana C Pimenta
Sep 2, 2021·The Journal of Infectious Diseases·Louise K Francois WatkinsChris A Van Beneden

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