High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
P LipponenV M Kosma

Abstract

Several epithelial tumours accumulate hyaluronan (HA) which promotes cancer cell invasion and metastasis. We analysed the expression of HA and its receptor CD44 and their prognostic value in 166 prostate cancer patients followed up for a mean of 13 years; standard deviation (S.D.) 2.7; range 8.7-21.4 years. HA was detected with a specific biotinylated probe prepared from cartilage aggrecan and link protein, and CD44 with an antibody recognising all forms of CD44. The peri- and intratumoral stroma from half of the patients strongly expressed immunohistochemically detectable HA in < or = 15% of the stromal area; the tumours in the remaining half expressed HA in > 15% of the area. The staining of cancer cells for HA was scored positive or negative, and for CD44 the median value of 80% of positive tumour cells was used as a cut-off point. The expression of HA in cancer cells was weakly associated with perineural infiltration of the tumour (P = 0.03) and high Gleason score (P = 0.002). There was also a significant inverse relationship between the expression of HA and CD44 in cancer cells (P < 0.001). The high level of HA in the peri-and intratumoral stroma was related to metastasis, high T-category, high Gleason score, perineural in...Continue Reading

References

Oct 1, 1978·American Journal of Surgery·S Kaufman, J M Loré
Jun 3, 1992·Journal of the National Cancer Institute·T VisakorpiJ Isola
Jun 1, 1992·The Journal of Cell Biology·C HardwickE A Turley
Oct 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J A RipellinoR K Margolis
Mar 3, 1995·International Journal of Cancer. Journal International Du Cancer·P RooneyM Wang
Aug 1, 1995·Journal of Cellular Physiology·U M AgrenR Tammi
Sep 1, 1995·Clinical & Experimental Metastasis·L M JonesG A Turner
Feb 1, 1995·The Prostate·S VesalainenK Syrjänen
Jan 1, 1994·Progress in Histochemistry and Cytochemistry·R TammiM Tammi
Nov 1, 1996·American Journal of Clinical Pathology·M NagabhushanM S Sy
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·P K AuvinenV M Kosma
Jun 30, 1998·International Journal of Cancer. Journal International Du Cancer·R T PirinenV M Kosma

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Citations

Jan 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hatem A El-MezayenEhab El-Badry
Apr 25, 2003·Critical Reviews in Oncology/hematology·Tracey A MartinWen G Jiang
Jul 2, 2004·Nature Reviews. Cancer·Bryan P Toole
Feb 10, 2012·Journal of the Royal Society, Interface·Nadja NijenhuisChristoph F Schmidt
May 30, 2008·Frontiers in Bioscience : a Journal and Virtual Library·Melanie A Simpson, Vinata B Lokeshwar
May 5, 2011·International Journal of Molecular Sciences·Miranda P WeenCarmela Ricciardelli
Oct 18, 2014·Cancer Metastasis Reviews·Anja SchmausJonathan P Sleeman
Oct 5, 2013·Journal of Biochemistry·Paraskevi HeldinKaoru Kahata
Mar 29, 2014·Journal of Cancer Research and Clinical Oncology·Hideo ShigeishiMasaaki Takechi
Jan 30, 2004·International Journal of Cancer. Journal International Du Cancer·Hanna TuhkanenArto Mannermaa
Aug 18, 2009·The Journal of Urology·Christopher S GomezVinata B Lokeshwar
Feb 28, 2016·Cancer Letters·Theerawut ChanmeeNaoki Itano
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Elizabeth J FranzmannVinata B Lokeshwar
Dec 23, 2003·Journal of Cellular Biochemistry·Ray B Nagle
Mar 10, 2011·International Journal of Cancer. Journal International Du Cancer·Hiroshi UrakawaNaoki Ishiguro
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Cynthia C SprengerMay J Reed
Aug 9, 2005·Pathologie-biologie·Robert Stern
Aug 7, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Laurent DavidJean-Pierre Vannier
Aug 30, 2005·Experimental Cell Research·Lishanthi UdabageTracey J Brown
Jun 28, 2005·Cancer Letters·Ashleigh HillDavid J J Waugh
Jul 16, 2005·Leukemia & Lymphoma·Thierry Vincent, Nadir Mechti
May 6, 2016·Frontiers in Oncology·Kekoa TaparraNatasha E Zachara
Mar 6, 2009·Cell Adhesion & Migration·Jong Bae ParkSeung-Hoon Lee
Jul 22, 2008·The Journal of Urology·Gul S DalginLouis S Liou
Oct 28, 2014·ACS Applied Materials & Interfaces·Shiyun ZhangQun Huo
Sep 11, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Peeter KarihtalaVeli-Matti Kosma
Aug 27, 2014·International Journal of Molecular Sciences·Lei Wang, Manuela Martins-Green
Dec 6, 2018·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Matheus Neves Ribeiro da SilvaMaria Aparecida da Silva Pinhal

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