High temperature induces cyp26b1 mRNA expression and delays meiotic initiation of germ cells by increasing cortisol levels during gonadal sex differentiation in Japanese flounder

Biochemical and Biophysical Research Communications
Toshiya Yamaguchi, Takeshi Kitano

Abstract

The Japanese flounder (Paralichthys olivaceus) is a teleost fish with an XX/XY sex determination system. XX flounder can be induced to develop into phenotypic females or males, by rearing them at 18°C or 27°C, respectively, during the sex differentiation period. Therefore, the flounder provides an excellent model to study the molecular mechanisms underlying temperature-dependent sex determination. We previously showed that cortisol, the major glucocorticoid produced by the interrenal cells in teleosts, causes female-to-male sex reversal by directly suppressing mRNA expression of ovary-type aromatase (cyp19a1), a steroidogenic enzyme responsible for the conversion of androgens to estrogens in the gonads. Furthermore, an inhibitor of cortisol synthesis prevented masculinization of XX flounder at 27°C, suggesting that masculinization by high temperature is due to the suppression of cyp19a1 mRNA expression by elevated cortisol levels during gonadal sex differentiation in the flounder. In the present study, we found that exposure to high temperature during gonadal sex differentiation upregulates the mRNA expression of retinoid-degrading enzyme (cyp26b1) concomitantly with masculinization of XX gonads and delays meiotic initiation of...Continue Reading

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Citations

Sep 17, 2013·PloS One·Adriana Rodríguez-MaríJohn H Postlethwait
Oct 24, 2013·Briefings in Functional Genomics·Woei Chang Liew, László Orbán
Aug 15, 2014·International Journal of Environmental Research and Public Health·Tan XuWenjie Sun
Oct 4, 2015·General and Comparative Endocrinology·Yukiko KikuchiKataaki Okubo
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Jun 19, 2013·General and Comparative Endocrinology·Juan I FernandinoGustavo M Somoza
Sep 16, 2014·Frontiers in Endocrinology·Diana C Castañeda CortésJuan I Fernandino
Dec 3, 2016·Sexual Development : Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation·Jean-François Baroiller, Helena D'Cotta
Sep 12, 2017·Reproduction : the Official Journal of the Society for the Study of Fertility·Alexander GoikoetxeaNeil J Gemmell
Jul 13, 2016·Journal of Fish Biology·F N ValentinL S O Nakaghi
Feb 5, 2019·Frontiers in Genetics·Alexandros TsakogiannisCostas S Tsigenopoulos
Sep 17, 2019·Annual Review of Animal Biosciences·Oscar Ortega-RecaldeNeil J Gemmell
Apr 12, 2020·Fish & Shellfish Immunology·Shuangshuang YangChenhao Yuan

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