High-throughput bacterial functional genomics in the sequencing era

Current Opinion in Microbiology
Andrew N GrayCarol A Gross

Abstract

High-throughput functional genomic technologies are accelerating progress in understanding the diversity of bacterial life and in developing a systems-level understanding of model bacterial organisms. Here we highlight progress in deep-sequencing-based functional genomics, show how whole genome sequencing is enabling phenotyping in organisms recalcitrant to genetic approaches, recount the rapid proliferation of functional genomic approaches to non-growth phenotypes, and discuss how advances are enabling genome-scale resource libraries for many different bacteria.

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Citations

Jan 23, 2016·Bioinformatics·Lars BarquistJulian Parkhill
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