High-throughput gas chromatography-mass spectrometry analysis of pesticide residues in spices by using the enhanced matrix removal-lipid and the sample dilution approach

Journal of Chromatography. a
E HakmeA R Fernández-Alba

Abstract

Spices are known as difficult matrices that contain variable amounts of fats, piperine or many other matrix constituents. The increasing sensitivity of new GC-MS/MS platforms opens new approaches to analyze pesticide residue in complex matrices such as spices, by sample dilution. The aim of this work is to develop and validate an effective multiresidue method for the analysis of pesticide residues in spices by GC-MS/MS. In this paper, we highlight the importance of reducing matrix interferences generated from co-extractive components of spices. Moreover, we emphasize the concern of obtaining clean extracts requiring less instrument maintenance. By evaluating the total ion chromatograms (TIC) on GC-Orbitrap-MS of different extracts using various sorbents, QuEChERS citrate using EMR-Lipid sorbent resulted in the cleanest extract among Z-Sep, Primary secondary amine (PSA), Oasis® Prime HLB, and Supelclean™ Ultra cartridges that consist of a top bed of PSA, C18 and Grashsphere™ 2031 and a bottom bed of Z-Sep. Later, the analyses were performed on a GC-QQQ-MS/MS, applying a 15 min runtime method covering 205 compounds. The samples were diluted 25 times before the injection bearing in mind that the instrumental LOQs reached (iLOQ) we...Continue Reading

Citations

Dec 11, 2020·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Yuxiao ZhuYongquan Zheng
Jan 5, 2021·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Shui WatanabeTsuneo Hashimoto
Nov 18, 2021·Analytical Methods : Advancing Methods and Applications·Qiaoying ChangFazheng Ren

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