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High-throughput genotyping of a full voltage-gated sodium channel gene via genomic DNA using target capture sequencing and analytical pipeline MoNaS to discover novel insecticide resistance mutations

PLoS Neglected Tropical Diseases

Nov 19, 2019

Kentaro ItokawaShinji Kasai

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PubMed

Abstract

In insects, the voltage-gated sodium channel (VGSC) is the primary target site of pyrethroid insecticides. Various amino acid substitutions in the VGSC protein, which are selected under insecticide pressure, are known to confer insecticide resistance. In the genome, the VGSC gene consis...read more

Mentioned in this Paper

Study
Voltage-Gated Sodium Channels
Exons
Genome
Genes
Voltage-gated Sodium Channel Complex
ACCN2 protein, human
Pyrethroids
Nucleic Acid Sequencing
Gene Mutation
5
7
Paper Details
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High-throughput genotyping of a full voltage-gated sodium channel gene via genomic DNA using target capture sequencing and analytical pipeline MoNaS to discover novel insecticide resistance mutations

PLoS Neglected Tropical Diseases

Nov 19, 2019

Kentaro ItokawaShinji Kasai

PMID: 31738756

DOI: 10.1371/journal.pntd.0007818

Abstract

In insects, the voltage-gated sodium channel (VGSC) is the primary target site of pyrethroid insecticides. Various amino acid substitutions in the VGSC protein, which are selected under insecticide pressure, are known to confer insecticide resistance. In the genome, the VGSC gene consis...read more

Mentioned in this Paper

Study
Voltage-Gated Sodium Channels
Exons
Genome
Genes
Voltage-gated Sodium Channel Complex
ACCN2 protein, human
Pyrethroids
Nucleic Acid Sequencing
Gene Mutation
5
7

Feeds With Similar Papers

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

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Paper Details
References
  • References38
  • Citations
1234
  • References38
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.

Download from

Publisher
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