Apr 12, 2020

Proliferation control of kidney interstitial cells

BioRxiv : the Preprint Server for Biology
S. S. McCarthyLeif Oxburgh


Expansion of interstitial cells in the adult kidney is a hallmark of chronic disease, whereas their proliferation during fetal development is necessary for organ formation. An intriguing difference between adult and neonatal kidneys is that the neonatal kidney has the capacity to control interstitial cell proliferation when the target number has been reached. In this study, we define the consequences of inactivating the TGF{beta}/Smad response in the interstitial cell lineage. We find that pathway inactivation through loss of Smad4 leads to over-proliferation of interstitial cells regionally in the kidney medulla. Genetic and molecular interaction studies showed that Smad3/4 participates in the Wnt/{beta}-catenin signaling pathway, which is responsible for promoting proliferation of interstitial cells. Specifically, Smad4 is required for the expression of the Wnt feedback inhibitor Apcdd1, and based on these findings we propose a model for interstitial cell proliferation control in which the Wnt/{beta}-catenin proliferative signal is attenuated by TGF{beta}/Smad signaling to ensure that proliferation ceases when the target number of interstitial cells has been reached in the neonatal medulla.

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Mentioned in this Paper

Small Nuclear RNA
Protein Methylation
Ribonucleoprotein Activity
Regulation of Biological Process
Complex (molecular entity)
Sequence Determinations

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