High-throughput integrated analyses for the tyrosinase-induced melanogenesis: microarray, proteomics and interactomics studies

Journal of Biomolecular Structure & Dynamics
Zhi-Rong LüJun-Mo Yang

Abstract

The tyrosinase gene was overexpressed in HEK293 cells, and then a DNA microarray and proteomic tools were applied to detect the dysregulated genes in highly pigmented cells. The candidate genes from the microarray were compared to the yeast two-hybridization results. Computational prediction via protein-protein interaction mapping suggested the existence of 66 hub genes in melanogenesis. Most importantly, RNA binding motif protein 9 is newly detected as a putative critical melanogenesis-associated gene in this study. The approach of combining the expression data analysis and predicted protein interaction partners performed in large scales can bring more reliable gene targets for understanding pigmentation.

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Citations

Jun 24, 2011·Journal of Biomolecular Structure & Dynamics·Ra'ed M Al-KhatibRosni Abdullah
Feb 8, 2011·Journal of Biomolecular Structure & Dynamics·Tung-Ti ChangCalvin Yu-Chian Chen
Feb 8, 2011·Journal of Biomolecular Structure & Dynamics·Smarajit DasJayprokas Chakrabarti
Feb 8, 2011·Journal of Biomolecular Structure & Dynamics·Xiaoqing LiuZerong He
Jun 15, 2012·Journal of Biomolecular Structure & Dynamics·Jun Cao, Feng Shi
May 12, 2012·Enzyme Research·Su-Fang WangGuo-Ying Qian
Jun 24, 2011·Journal of Biomolecular Structure & Dynamics·Joydeep Chakraborty, Tapan K Dutta
Jun 28, 2019·Journal of Biomolecular Structure & Dynamics·Shang-Jun YinJun-Mo Yang
Aug 31, 2011·Journal of Biomolecular Structure & Dynamics·Alexander FavorovMichael F Ochs
Dec 15, 2010·Journal of Biomolecular Structure & Dynamics·Yusen Zhang, Wei Chen
Aug 31, 2011·Journal of Biomolecular Structure & Dynamics·Zhou GongYi Xiao
Dec 15, 2010·Journal of Biomolecular Structure & Dynamics·Guisong Chang, Tianming Wang
Nov 10, 2011·Journal of Biomolecular Structure & Dynamics·Shang-Jun YinYong-Doo Park
Dec 15, 2010·Journal of Biomolecular Structure & Dynamics·Jun CaoGuang Huang
Feb 2, 2012·Journal of Biomolecular Structure & Dynamics·Yue-Xiu SiGuo-Ying Qian
Aug 31, 2011·Journal of Biomolecular Structure & Dynamics·Meng-Ze DuYue-Yun Chen

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Methods Mentioned

BETA
electrophoresis

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